Sandbox Reserved 829: Difference between revisions

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Morover, it is important to note that PDX-1 is located in the nucleus of cells.

PDX-1 contains, at the N-terminus, a transactivation domain ( from 1 to 79 amino acids) and the middle region of the protein is composed of a homeodomain (from 146 to 206 amino acids) which is essential for DNA binding and protein-protein interactions. It plays a key role in the pancreatic development, the β-cell maturation and survival. Indeed, transcription factors play an important role in gene regulation by recognizing specific DNA control regions associated with each gene. That is why a modification in the structure of the transcription factor can affect the regulation of the gene and so cause different diseases. In our case, PDX-1 modifications can lead to a type II diabetes.

PDX-1 contains, at the N-terminus, a transactivation domain ( from 1 to 79 amino acids) and the middle region of the protein is composed of a homeodomain (from 146 to 206 amino acids) which is essential for DNA binding and protein-protein interactions.

[[Image:Schematic representation of functional domains and phosphorylation sites of PDX-1.jpg|left|600px|thumb|Schematic representation of functional domains and phosphorylation sites of PDX-1]]

The homeodomain plays a key role in the pancreatic development, the β-cell maturation and survival. Indeed, transcription factors play an important role in gene regulation by recognizing specific DNA control regions associated with each gene. That is why a modification in the structure of the transcription factor can affect the regulation of the gene and so cause different diseases. In our case, PDX-1 modifications can lead to a type II diabetes.

The DNA binding domains of transcription factors belong to evolutionarily conserved families including homeodomain family.

== '''Structure of PDX-1 homeodomain''' ==

Sandbox Reserved 829: Difference between revisions

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@@ Line 12: / Line 12: @@
 Morover, it is important to note that PDX-1 is located in the nucleus of cells.
-PDX-1 contains, at the N-terminus, a transactivation domain ( from 1 to 79 amino acids) and the middle region of the protein is composed of a homeodomain (from 146 to 206 amino acids) which is essential for DNA binding and protein-protein interactions. It plays a key role in the pancreatic development, the  β-cell maturation and survival. Indeed, transcription factors play an important role in gene regulation by recognizing specific DNA control regions associated with each gene. That is why a modification in the structure of the transcription factor can affect the regulation of the gene and so cause different diseases. In our case, PDX-1 modifications can lead to a type II diabetes.
+PDX-1 contains, at the N-terminus, a transactivation domain ( from 1 to 79 amino acids) and the middle region of the protein is composed of a homeodomain (from 146 to 206 amino acids) which is essential for DNA binding and protein-protein interactions.
+[[Image:Schematic representation of functional domains and phosphorylation sites of PDX-1.jpg|left|600px|thumb|Schematic representation of functional domains and phosphorylation sites of PDX-1]]
+The homeodomain plays a key role in the pancreatic development, the  β-cell maturation and survival. Indeed, transcription factors play an important role in gene regulation by recognizing specific DNA control regions associated with each gene. That is why a modification in the structure of the transcription factor can affect the regulation of the gene and so cause different diseases. In our case, PDX-1 modifications can lead to a type II diabetes.
 The DNA binding domains of transcription factors belong to evolutionarily conserved families including homeodomain family.
 == '''Structure of PDX-1 homeodomain''' ==