Sandbox Reserved 829: Difference between revisions

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=='''Introduction''' ==
=='''Introduction''' ==


Pancreatic and Duodenal homeoboX 1, called PDX-1, is a transcription factor which is encoded by the gene ''Ipf1''. This one is located at the human chromosome 13q12.1.
[[Image:Cytogenetic location of the PDX-1 gene (chromosom 13q12.1).jpg|left|300px|thumb|The cytogenetic location of the PDX-1 gene (''Ipf1'') is on the chromosome 13q12.1]]
Human PDX-1 is a protein of 283 amino acids with a molecular weight of 30,64 kDa. This transcription factor belongs to the ParaHox transcription factor family, which diverged from the Hox subfamily through a duplication event.
 
Morover, it is important to note that PDX-1 is located in the nucleus of cells.
 
 
 
 
 


PDX-1 contains, at the N-terminus, a transactivation domain ( from 1 to 79 amino acids) and the middle region of the protein is composed of a homeodomain (from 146 to 206 amino acids) which is essential for DNA binding and protein-protein interactions.
[[Image:Schematic representation of functional domains and phosphorylation sites of PDX-1.jpg|left|600px|thumb|Schematic representation of functional domains and phosphorylation sites of PDX-1]]


Pancreatic and Duodenal homeoboX 1, called PDX-1, is a transcription factor which is encoded by the gene ''Ipf1''. This one is located at the human chromosome 13q12.1.




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Human PDX-1 is a protein of 283 amino acids with a molecular weight of 30,64 kDa. This transcription factor belongs to the ParaHox transcription factor family, which diverged from the Hox subfamily through a duplication event.
Morover, it is important to note that PDX-1 is located in the nucleus of cells.


[[Image:Schematic representation of functional domains and phosphorylation sites of PDX-1.jpg|right|600px|thumb|Schematic representation of functional domains and phosphorylation sites of PDX-1]]




PDX-1 contains, at the N-terminus, a transactivation domain ( from 1 to 79 amino acids) and the middle region of the protein is composed of a homeodomain (from 146 to 206 amino acids) which is essential for DNA binding and protein-protein interactions.




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The DNA binding domains of transcription factors belong to evolutionarily conserved families including homeodomain family.
The DNA binding domains of transcription factors belong to evolutionarily conserved families including homeodomain family.


== '''Structure of PDX-1 homeodomain''' ==  
== '''Structure of PDX-1 homeodomain''' ==  
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