Sandbox Reserved 820: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
<Structure load='2vaf' size='500' frame='true' align='right' caption='Crystal Structure of Human Cardiac Calsequestrin, (PDB code [[2vaf]]) ' scene='56/568018/General_structure/4'/> | <Structure load='2vaf' size='500' frame='true' align='right' caption='Crystal Structure of Human Cardiac Calsequestrin, (PDB code [[2vaf]]) ' scene='56/568018/General_structure/4'/> | ||
'''Calsequestrin-2''' (or '''CASQ2''') is the soluble | '''Calsequestrin-2''' (or '''CASQ2''') is the soluble Ca<sup>2+</sup> binding protein in the sarcoplasmic reticulum lumen of the cardiac muscle cells. CASQ2 could be either in a monomeric, homodimeric, or homooligomeric chain form depending on its bounds with Ca<sup>2+</sup>. Mutations of CASQ2 are involved in cardiac diseases such as Catecholaminergic Polymorphic Ventricular Tachycardia. | ||
[[Image:LoadBinary 004.gif|300px|left|thumb|Calsequestrin in the calcium cycle of myocyte contraction]] | [[Image:LoadBinary 004.gif|300px|left|thumb|Calsequestrin in the calcium cycle of myocyte contraction]] | ||
