Sandbox Reserved 822: Difference between revisions
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{{Sandbox_Reserved_ESBS}} | {{Sandbox_Reserved_ESBS}} | ||
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{{STRUCTURE_1w1h| PDB=1w1h | SCENE= }} | |||
== Description == | == '''Description''' == | ||
1w1h is the human pleckstrin homology (PH) domain of the 3-phosphoinositide-dependent protein kinase 1 (PDK1), which plays a various role in PI3K signaling pathways. | |||
PDK1 contains 556 amino acids and phosphorylates and activates at least 24 Proteins of the AGC family of protein kinases. It therefore consists of a N-terminal Ser/Thr kinase catalytic domain (residues 71-359) and the C-terminal pleckstrin homology (PH) domain (residues 459-550). | |||
PDK1 is activated by binding of its PH domain to specific target molecules like phosphoinositides or phosphoatityl inositides and can then interact with its target substrates. | |||
Even though the targeting of PDK1 to specific locations of the cell is not fully understand in detail, it has been proven that the binding of its PH domain to target molecules plays a central role in this process. | |||
== '''Structure''' == | |||
