Sandbox Reserved 825: Difference between revisions

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=='''FRB Domain'''==
=='''FRB Domain'''==
The mammalian target of rapamycin (mTOR) is a protein that is intricately involved in signaling pathways controlling cell growth. Rapamycin is a natural product that binds and inhibits mTOR function by interacting with its FKBP-rapamycin-binding (FRB) domain (or '''2NPU''')


mTOR is highly conserved across all eukaryotes, with 40–60% amino-acid sequence identity.
mTOR is highly conserved across all eukaryotes, with 40–60% amino-acid sequence identity.
mTOR contains a number of distinct functional domains including up to''' The FRB domain''' of '''mTOR''' (or '''2NPU''') which is responsible for the binding of the inhibitory cyclic macrolide '''Rapamycin'''

Revision as of 13:24, 30 December 2013

This Sandbox is Reserved from 06/12/2018, through 30/06/2019 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1480 through Sandbox Reserved 1543.
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FRB Domain

The mammalian target of rapamycin (mTOR) is a protein that is intricately involved in signaling pathways controlling cell growth. Rapamycin is a natural product that binds and inhibits mTOR function by interacting with its FKBP-rapamycin-binding (FRB) domain (or 2NPU)

mTOR is highly conserved across all eukaryotes, with 40–60% amino-acid sequence identity.

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