Sandbox Reserved 829: Difference between revisions
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===='''Motifs of the PDX-1 homeodomain'''==== | ===='''Motifs of the PDX-1 homeodomain'''==== [[http://www.proteopedia.org/wiki/index.php/Image:Schematic_representation_of_functional_domains_and_phosphorylation_sites_of_PDX-1.jpg]] | ||
The homeodomain contains a Protein Transduction Domain (PTD : from 188 to 203 amino acids) and a Nuclear Localization Signal motif (NLS : from 197 to 203 amino acids), which allow PDX-1 to permeate into cells. | The homeodomain contains a Protein Transduction Domain (PTD : from 188 to 203 amino acids) and a Nuclear Localization Signal motif (NLS : from 197 to 203 amino acids), which allow PDX-1 to permeate into cells. | ||
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[[Image:Nter.jpg|left|500px|thumb|PDX-1 homedomain/DNA interactions | [[Image:Nter.jpg|left|500px|thumb|PDX-1 homedomain/DNA interactions | ||
A. Structure of the PDX-1 homedomain/DNA complex | A. Structure of the PDX-1 homedomain/DNA complex | ||
B. Hydrogen bond contacts with the DNA differ between Conformation A and B | B. Hydrogen bond contacts with the DNA differ between Conformation A and B | ||
<ref> PMID: 23950697</ref> ]] | <ref> PMID: 23950697</ref> ]] | ||
