Sandbox Reserved 829: Difference between revisions
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Nuclear translocation of transcription factors is a crucial requirement for their action and stimulus-dependent nuclear translocation can serve as a mechanism to regulate gene expression at the level of transcription initiation. | Nuclear translocation of transcription factors is a crucial requirement for their action and stimulus-dependent nuclear translocation can serve as a mechanism to regulate gene expression at the level of transcription initiation. | ||
NLS is composed of several basic amino acids such as arginine (R) and lysine (K), as we can see in the NLS sequence RRMKWKK (basic amino acids) of PDX-1. This motif is sufficient for the nuclear import of PDX-1.<ref>PMID : 10567702</ref> | NLS is composed of several basic amino acids such as arginine (R) and lysine (K), as we can see in the NLS sequence RRMKWKK (basic amino acids) of PDX-1. This motif is sufficient for the nuclear import of PDX-1.<ref>PMID : 10567702</ref> | ||
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http://atlasgeneticsoncology.org/Genes/PDX1ID43921ch13q12.html | http://atlasgeneticsoncology.org/Genes/PDX1ID43921ch13q12.html | ||
http://ghr.nlm.nih.gov/gene/PDX1 | http://ghr.nlm.nih.gov/gene/PDX1 | ||
http://diabetes.diabetesjournals.org/content/51/suppl_3/S320.long | http://diabetes.diabetesjournals.org/content/51/suppl_3/S320.long | ||
