2mio: Difference between revisions

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~~{{STRUCTURE_2mio| PDB=2mio | SCENE= }}~~

==Solution NMR Structure of SH3 Domain 1 of Rho GTPase-activating Protein 10 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR9129A==

===Solution NMR Structure of SH3 Domain 1 of Rho GTPase-activating Protein 10 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR9129A===

== Structural highlights ==

==~~Function~~==

<table><tr><td colspan='2'>[[2mio]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIO FirstGlance]. <br>

[[http://~~www~~.~~uniprot~~.org/~~uniprot~~/~~RHG10_HUMAN RHG10_HUMAN~~]] ~~GTPase activator for~~ the ~~small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state~~. ~~Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases~~. ~~Inhibits PAK2 proteolytic fragment PAK~~-~~2p34 kinase activity and changes its localization from the nucleus to the perinuclear region~~. ~~Stabilizes PAK-2p34 thereby increasing stimulation of cell death~~ (~~By similarity~~).

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARHGAP10, GRAF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mio OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mio RCSB], [http://www.ebi.ac.uk/pdbsum/2mio PDBsum]</span></td></tr>

==~~About this Structure~~==

</table>

[[2mio]~~] is a 1 chain structure. Full experimental information is available from~~ [http://oca.weizmann.ac.il/oca-bin/~~ocashort~~?id=~~2MIO~~ OCA].

__TOC__

[[Category: Eletsky, A.]]

</StructureSection>

[[Category: Everett, J K.]]

[[Category: Human]]

[[Category: Janjua, H.]]

[[Category: Eletsky, A]]

[[Category: Montelione, G T.]]

[[Category: Everett, J K]]

[[Category: ~~NESG, Northeast~~ Structural ~~Genomics Consortium.~~]]

[[Category: Janjua, H]]

[[Category: Pulavarti, S V.S R.K.]]

[[Category: Montelione, G T]]

[[Category: Sukumaran, D K.]]

[[Category: Structural genomic]]

[[Category: Szyperski, T.]]

[[Category: Pulavarti, S V.S R.K]]

[[Category: Wang, H.]]

[[Category: Sukumaran, D K]]

[[Category: Xiao, R.]]

[[Category: Szyperski, T]]

[[Category: Xu, X.]]

[[Category: Wang, H]]

[[Category: Xiao, R]]

[[Category: Xu, X]]

[[Category: Nesg]]

[[Category: ~~Northeast structural genomics consortium]]~~

[[Category: PSI, Protein structure initiative]]

~~[[Category:~~ Protein structure initiative]]

[[Category: Psi-biology]]

~~[[Category: Structural genomic]]~~

[[Category: Unknown function]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_2mio|  PDB=2mio  |  SCENE=  }}
+==Solution NMR Structure of SH3 Domain 1 of Rho GTPase-activating Protein 10 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR9129A==
-===Solution NMR Structure of SH3 Domain 1 of Rho GTPase-activating Protein 10 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR9129A===
+<StructureSection load='2mio' size='340' side='right' caption='[[2mio]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+== Structural highlights ==
-==Function==
+<table><tr><td colspan='2'>[[2mio]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIO FirstGlance]. <br>
-[[http://www.uniprot.org/uniprot/RHG10_HUMAN RHG10_HUMAN]] GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARHGAP10, GRAF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mio OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mio RCSB], [http://www.ebi.ac.uk/pdbsum/2mio PDBsum]</span></td></tr>
-==About this Structure==
+</table>
-[[2mio]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIO OCA].
+__TOC__
-[[Category: Eletsky, A.]]
+</StructureSection>
-[[Category: Everett, J K.]]
+[[Category: Human]]
-[[Category: Janjua, H.]]
+[[Category: Eletsky, A]]
-[[Category: Montelione, G T.]]
+[[Category: Everett, J K]]
-[[Category: NESG, Northeast Structural Genomics Consortium.]]
+[[Category: Janjua, H]]
-[[Category: Pulavarti, S V.S R.K.]]
+[[Category: Montelione, G T]]
-[[Category: Sukumaran, D K.]]
+[[Category: Structural genomic]]
-[[Category: Szyperski, T.]]
+[[Category: Pulavarti, S V.S R.K]]
-[[Category: Wang, H.]]
+[[Category: Sukumaran, D K]]
-[[Category: Xiao, R.]]
+[[Category: Szyperski, T]]
-[[Category: Xu, X.]]
+[[Category: Wang, H]]
+[[Category: Xiao, R]]
+[[Category: Xu, X]]
 [[Category: Nesg]]
-[[Category: Northeast structural genomics consortium]]
+[[Category: PSI, Protein structure initiative]]
-[[Category: Protein structure initiative]]
 [[Category: Psi-biology]]
-[[Category: Structural genomic]]
 [[Category: Unknown function]]