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In order to regulate all of these genes, PDX1 interacts with different cofactors.

In pancreatic δ-cells, PDX-1 interacts with PBX1 and PREP1 corresponding respectively to PBC and MEIS proteins. These proteins belong to the three amino acids loop extension (TALE) family of homeodomains. By interacting with these proteins, PDX-1 can regulate the somatostatin promoter. Interaction with the TALE proteins is mediated through a conserved pentapeptide motif, FPWMK, located ~~at the 10 residues of~~ the N-terminal of the homeodomain. <ref>PMID : 11279116</ref>

In pancreatic δ-cells, PDX-1 interacts with PBX1 and PREP1 corresponding respectively to PBC and MEIS proteins. These proteins belong to the three amino acids loop extension (TALE) family of homeodomains. By interacting with these proteins, PDX-1 can regulate the somatostatin promoter. Interaction with the TALE proteins is mediated through a conserved pentapeptide motif, FPWMK, located in the N-terminal region of the protein and separated from the homeodomain by around 10 residues. <ref>PMID : 11279116</ref>

In neural cells, PDX-1 utilizes a different binding site on the somatostatin promoter than in δ-cells, suggesting a distinct protein complex. PDX-1 interacts also with the basic helix-loop-helix (bHLH: [http://en.wikipedia.org/wiki/Basic_helix-loop-helix Wikipedia]) factor E47/NeuroD.

Sandbox Reserved 829: Difference between revisions

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@@ Line 192: / Line 192: @@
 In order to regulate all of these genes, PDX1 interacts with different cofactors.
-In pancreatic δ-cells, PDX-1 interacts with PBX1 and PREP1 corresponding respectively to PBC and MEIS proteins. These proteins belong to the three amino acids loop extension (TALE) family of homeodomains. By interacting with these proteins, PDX-1 can regulate the somatostatin promoter. Interaction with the TALE proteins is mediated through a conserved pentapeptide motif, FPWMK, located at the 10 residues of the N-terminal of the homeodomain. <ref>PMID : 11279116</ref>
+In pancreatic δ-cells, PDX-1 interacts with PBX1 and PREP1 corresponding respectively to PBC and MEIS proteins. These proteins belong to the three amino acids loop extension (TALE) family of homeodomains. By interacting with these proteins, PDX-1 can regulate the somatostatin promoter. Interaction with the TALE proteins is mediated through a conserved pentapeptide motif, FPWMK, located in the N-terminal region of the protein and separated from the homeodomain by around 10 residues. <ref>PMID : 11279116</ref>
 In neural cells, PDX-1 utilizes a different binding site on the somatostatin promoter than in δ-cells, suggesting a distinct protein complex. PDX-1 interacts also with the basic helix-loop-helix (bHLH: [http://en.wikipedia.org/wiki/Basic_helix-loop-helix Wikipedia]) factor E47/NeuroD.