2bib: Difference between revisions
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==Overview== | ==Overview== | ||
Phosphorylcholine, a specific component of the pneumococcal cell wall, is, crucial in pathogenesis. It directly binds to the human, platelet-activating factor (PAF) receptor and acts as a docking station, for the family of surface-located choline-binding proteins (CBP). The, first structure of a complete pneumococcal CBP, Pce (or CbpE), has been, solved in complex with the reaction product and choline analogs. Pce has a, novel modular structure, with a globular N-terminal module containing a, binuclear Zn(2+) catalytic center, and an elongated choline-binding, module. Residues involved in substrate binding and catalysis are described, and modular configuration of the active center accounts for in vivo, features of teichoic acid hydrolysis. The hydrolysis of PAF by Pce and its, regulatory . | Phosphorylcholine, a specific component of the pneumococcal cell wall, is, crucial in pathogenesis. It directly binds to the human, platelet-activating factor (PAF) receptor and acts as a docking station, for the family of surface-located choline-binding proteins (CBP). The, first structure of a complete pneumococcal CBP, Pce (or CbpE), has been, solved in complex with the reaction product and choline analogs. Pce has a, novel modular structure, with a globular N-terminal module containing a, binuclear Zn(2+) catalytic center, and an elongated choline-binding, module. Residues involved in substrate binding and catalysis are described, and modular configuration of the active center accounts for in vivo, features of teichoic acid hydrolysis. The hydrolysis of PAF by Pce and its, regulatory role in phosphorylcholine decoration of the bacterial surface, provide new insights into the critical function of Pce in pneumococcal, adherence and invasiveness. | ||
==About this Structure== | ==About this Structure== | ||
2BIB is a | 2BIB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae] with ZN, CA, PC and BTB as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BIB OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: teichoic acid]] | [[Category: teichoic acid]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 15:22:06 2007'' | ||
