Sandbox Reserved 820: Difference between revisions
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<!-- Source: Regulation of Ryanodine Receptors by Calsequestrin: Effect of High Luminal Ca2+ and Phosphorylation (Beard et Al., 2005) Lien: http://www.ncbi.nlm.nih.gov/pubmed/15731387 --> | <!-- Source: Regulation of Ryanodine Receptors by Calsequestrin: Effect of High Luminal Ca2+ and Phosphorylation (Beard et Al., 2005) Lien: http://www.ncbi.nlm.nih.gov/pubmed/15731387 --> | ||
== Regulation of CASQ2 == | == Regulation of CASQ2 == | ||
CASQ2 can be phosphorylated by three different kinases: casein kinase I (CK I), casein kianse II (CK II) and ε protein kinase C1 (εPKC1).<ref name="Calsequestrin and the calcium release channel of skeletal and cardiac muscle (Beard et Al., 2004)">http://www.ncbi.nlm.nih.gov/pubmed/15050380</ref> CK II is located in the SR and is able to phosphorylate Ser 378, Ser 382 and Ser 386. These residues are on the C-terminal domain.<ref name="Calsequestrin and the calcium release channel of skeletal and cardiac muscle (Beard et Al., 2004)">http://www.ncbi.nlm.nih.gov/pubmed/15050380</ref> The consensus sequence recognized by CK II is Ser/Thr-X-X-Asp/Glu. <ref name="Calsequestrin and the calcium release channel of skeletal and cardiac muscle (Beard et Al., 2004)">http://www.ncbi.nlm.nih.gov/pubmed/15050380</ref>More there are acidic residues after this consensus sequence, more the probabilty of phosphorylation increases.<ref name="Calsequestrin and the calcium release channel of skeletal and cardiac muscle (Beard et Al., 2004)">http://www.ncbi.nlm.nih.gov/pubmed/15050380</ref> | CASQ2 can be phosphorylated by three different kinases: casein kinase I (CK I), casein kianse II (CK II) and ε protein kinase C1 (εPKC1).<ref name="Calsequestrin and the calcium release channel of skeletal and cardiac muscle (Beard et Al., 2004)">http://www.ncbi.nlm.nih.gov/pubmed/15050380</ref> CK II is located in the SR and is able to phosphorylate Ser 378, Ser 382 and Ser 386. These residues are on the C-terminal domain.<ref name="Calsequestrin and the calcium release channel of skeletal and cardiac muscle (Beard et Al., 2004)">http://www.ncbi.nlm.nih.gov/pubmed/15050380</ref> The consensus sequence recognized by CK II is Ser/Thr-X-X-Asp/Glu. <ref name="Calsequestrin and the calcium release channel of skeletal and cardiac muscle (Beard et Al., 2004)">http://www.ncbi.nlm.nih.gov/pubmed/15050380</ref>More there are acidic residues after this consensus sequence, more the probabilty of phosphorylation increases.<ref name="Calsequestrin and the calcium release channel of skeletal and cardiac muscle (Beard et Al., 2004)">http://www.ncbi.nlm.nih.gov/pubmed/15050380</ref> | ||
