Sandbox Reserved 820: Difference between revisions

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The contractions of cardiac myocytes are triggered by the increase of calcium concentration in the cytosol. This phenomenon is highly controlled at several levels. First the calcium is stocked in a cell compartment called the sarcoplasmic reticulum. Then the release of calcium in the cytosol is dependent of the myocytes membrane depolarization. Finally the release of calcium is extremely brief, as soon as the depolarization is over, the calcium is actively pumped in the sarcoplasmic reticulum.

The calsequestrin 2 plays a major role here, because it helps the release of the calcium in the cytosol while the membrane depolarization occurs and traps the calcium inside the lumen of the sarcoplasmic reticulum. <ref name="CASQ2 role">CASQ2 calsequestrin 2 ~~NCBI Ressource~~ http://www.ncbi.nlm.nih.gov/gene/845</ref>

The calsequestrin 2 plays a major role here, because it helps the release of the calcium in the cytosol while the membrane depolarization occurs and traps the calcium inside the lumen of the sarcoplasmic reticulum. <ref name="CASQ2 role">NCBI Ressource: CASQ2 calsequestrin 2 http://www.ncbi.nlm.nih.gov/gene/845</ref>

It is also good to notice that a huge release of calcium in the cytosol would be lethal to the cell, since the calcium would precipitate with the free phosphate groups.

Sandbox Reserved 820: Difference between revisions

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 The contractions of cardiac myocytes are triggered by the increase of calcium concentration in the cytosol. This phenomenon is highly controlled at several levels. First the calcium is stocked in a cell compartment called the sarcoplasmic reticulum. Then the release of calcium in the cytosol is dependent of the myocytes membrane depolarization. Finally the release of calcium is extremely brief, as soon as the depolarization is over, the calcium is actively pumped in the sarcoplasmic reticulum.
-The calsequestrin 2 plays a major role here, because it helps the release of the calcium in the cytosol while the membrane depolarization occurs and traps the calcium inside the lumen of the sarcoplasmic reticulum. <ref name="CASQ2 role">CASQ2 calsequestrin 2 NCBI Ressource http://www.ncbi.nlm.nih.gov/gene/845</ref>
+The calsequestrin 2 plays a major role here, because it helps the release of the calcium in the cytosol while the membrane depolarization occurs and traps the calcium inside the lumen of the sarcoplasmic reticulum. <ref name="CASQ2 role">NCBI Ressource: CASQ2 calsequestrin 2  http://www.ncbi.nlm.nih.gov/gene/845</ref>
 It is also good to notice that a huge release of calcium in the cytosol would be lethal to the cell, since the calcium would precipitate with the free phosphate groups.