Sandbox Reserved 827: Difference between revisions
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{{Sandbox_Reserved_ESBS}} | {{Sandbox_Reserved_ESBS}} | ||
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TBK1 stands for Tank Binding Kinase 1. This enzyme is a cytoplasmic serine-threonine kinase, coded by EC=2.7.11.1. It catalyzes the transfer of a phosphate group from an ATP onto a protein, in order to form a phosphoprotein and an ADP. Its primary sequence is 729 residues long. This homodimere is involved in several signalization pathways such as the inhibition of apoptosis, inflammatory response. Its substrates are NF-κ-B, various IRFs (interferon regulatory factors), | TBK1 stands for Tank Binding Kinase 1. This enzyme is a cytoplasmic serine-threonine kinase, coded by EC=2.7.11.1. It catalyzes the transfer of a phosphate group from an ATP onto a protein, in order to form a phosphoprotein and an ADP. Its primary sequence is 729 residues long. This homodimere is involved in several signalization pathways such as the inhibition of apoptosis, inflammatory response. Its substrates are NF-κ-B, various IRFs (interferon regulatory factors), DDX3X. It is involved in several complexes depending on the cell type and the stimuli. | ||
<Structure load='4IM3' size='400' frame='true' align='right' caption='TBK1' scene='Insert optional scene name here' /> | <Structure load='4IM3' size='400' frame='true' align='right' caption='TBK1' scene='Insert optional scene name here' /> | ||
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= Possible residue modifications = | = Possible residue modifications = | ||
<Structure load='4IM3' size='400' frame='true' align='right' caption='TBK1' scene='Insert optional scene name here' /> | |||
Several residues of TBK1 can be modified, by phosphorylation or polyubiquitination. | Several residues of TBK1 can be modified, by phosphorylation or polyubiquitination. | ||
