Sandbox Reserved 822: Difference between revisions
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== '''Description''' == | == '''Description''' == | ||
1w1h is the human pleckstrin homology (PH) domain of the 3-phosphoinositide-dependent protein kinase 1 (PDK1), which plays a various role in PI3K signaling pathways. | 1w1h is a 4 chain structure of the human pleckstrin homology (PH) domain of the 3-phosphoinositide-dependent protein kinase 1 (PDK1), which plays a various role in PI3K signaling pathways. | ||
PDK1 contains 556 amino acids and phosphorylates and activates at least 24 Proteins of the AGC (cAMP-dependent, cGMP-dependent, protein kinase C (PKC)) family of protein kinases. It therefore consists of a N-terminal Ser/Thr kinase catalytic domain (residues 71-359) and the C-terminal pleckstrin homology (PH) domain (residues 459-550). | PDK1 contains 556 amino acids and phosphorylates and activates at least 24 Proteins of the AGC (cAMP-dependent, cGMP-dependent, protein kinase C (PKC)) family of protein kinases. It therefore consists of a N-terminal Ser/Thr kinase catalytic domain (residues 71-359) and the C-terminal pleckstrin homology (PH) domain (residues 459-550). | ||
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== '''Structure''' == | == '''Structure''' == | ||
The structure 1W1H has in total 4 chains. These are represented by 1 sequence-unique entity. | |||
The PH domain of PDK1 reveals a structural variation of a standard PH domain fold with an additional bud at the N-terminus. | |||
Connsidering the structure, several different sections can be found which explain altogether the function of the PH domain. | |||
One section is a <scene name='56/568020/Barrel-like/3'>barrel-like structure</scene> formed by residues 456-530. | |||
