Sandbox Reserved 818: Difference between revisions
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==Binding of pertussis toxin to its cellular targets== | ==Binding of pertussis toxin to its cellular targets== | ||
After being secreted, pertussis toxin (PTX) can interact with almost all mammalian cells, which explains the variety of biological activities of the toxin. <br /> | After being secreted, pertussis toxin (PTX) can interact with almost all mammalian cells, which explains the variety of biological activities of the toxin. <br /> | ||
No specific receptors for PTX have been identified but many cell surface '''sialoglycoproteins''' are involved in the binding of PTX, together with '''glycoproteins'''. <br /> | No specific receptors for PTX have been identified but many cell surface '''sialoglycoproteins''' are involved in the binding of PTX, together with '''glycoproteins''': sugar moieties allow the recognition of the toxin and the carbohydrate sequence '''NeuAcα(2,6)-Galβ4GlcNAc''' is particularly important but sugar sequence alone is not sufficient. <br /> | ||
PTX binds its target cells through the B oligomer. | PTX binds its target cells through the B oligomer: . | ||
==Toxin entry and trafficking in target cells== | ==Toxin entry and trafficking in target cells== | ||
