Sandbox Reserved 813: Difference between revisions

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==Pou-homeodomain==

The homeodomain (POUhd) is a very conserved 60 amino acid '''three helices alpha DNA-binding domain'''. We can find the homeodomain form the 223th to the 282th amino acid in the Oct-4 sequence.Its DNA sequence is called the “homeobox”, and the genes are known as “Hox gene”. The DNA recognition helix (alpha 3) binds the DNA major groove while the amino-terminal tail binds the DNA minor groove. We can draw a parallel with oct1 and oct2 about the Homeodomain and admit that the ninth residue of the DNA-recognition helix is a cysteine that might have been conserved at this position to confer DNA binding specificity , and promote more relaxed DNA sequence recognition by POU domains. The recognition helix and the inter-helix loops are rich in arginine and lysine residues, which form hydrogen bonds to the DNA backbone.

The <scene name='56/568011/Pouhd/1'>homeodomain</scene> (POUhd) is a very conserved 60 amino acid '''three helices alpha DNA-binding domain'''. We can find the homeodomain form the 223th to the 282th amino acid in the Oct-4 sequence.Its DNA sequence is called the “homeobox”, and the genes are known as “Hox gene”. The DNA recognition helix (alpha 3) binds the DNA major groove while the amino-terminal tail binds the DNA minor groove. We can draw a parallel with oct1 and oct2 about the Homeodomain and admit that the ninth residue of the DNA-recognition helix is a cysteine that might have been conserved at this position to confer DNA binding specificity , and promote more relaxed DNA sequence recognition by POU domains. The recognition helix and the inter-helix loops are rich in arginine and lysine residues, which form hydrogen bonds to the DNA backbone.

Sandbox Reserved 813: Difference between revisions

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Revision as of 20:22, 6 January 2014 view source Sarah Welly (talk \| contribs) 119 edits No edit summary ← Older edit		Revision as of 20:29, 6 January 2014 view source Sarah Welly (talk \| contribs) 119 edits No edit summary Newer edit →
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	==Pou-homeodomain==		==Pou-homeodomain==

	The homeodomain (POUhd) is a very conserved 60 amino acid '''three helices alpha DNA-binding domain'''. We can find the homeodomain form the 223th to the 282th amino acid in the Oct-4 sequence.Its DNA sequence is called the “homeobox”, and the genes are known as “Hox gene”. The DNA recognition helix (alpha 3) binds the DNA major groove while the amino-terminal tail binds the DNA minor groove. We can draw a parallel with oct1 and oct2 about the Homeodomain and admit that the ninth residue of the DNA-recognition helix is a cysteine that might have been conserved at this position to confer DNA binding specificity , and promote more relaxed DNA sequence recognition by POU domains. The recognition helix and the inter-helix loops are rich in arginine and lysine residues, which form hydrogen bonds to the DNA backbone.		The <scene name='56/568011/Pouhd/1'>homeodomain</scene> (POUhd) is a very conserved 60 amino acid '''three helices alpha DNA-binding domain'''. We can find the homeodomain form the 223th to the 282th amino acid in the Oct-4 sequence.Its DNA sequence is called the “homeobox”, and the genes are known as “Hox gene”. The DNA recognition helix (alpha 3) binds the DNA major groove while the amino-terminal tail binds the DNA minor groove. We can draw a parallel with oct1 and oct2 about the Homeodomain and admit that the ninth residue of the DNA-recognition helix is a cysteine that might have been conserved at this position to confer DNA binding specificity , and promote more relaxed DNA sequence recognition by POU domains. The recognition helix and the inter-helix loops are rich in arginine and lysine residues, which form hydrogen bonds to the DNA backbone.