Sandbox Reserved 821: Difference between revisions
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Léa Chuzel (talk | contribs) No edit summary |
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Different sites of the CRP are needed to bind phosphocholine: | Different sites of the CRP are needed to bind phosphocholine: | ||
- A hydrophobic pocket with the two key residues Phe66 and Glu81 located on the two extremities of the cavity. Phe66 interacts with the methyl group of the phosphocholine by hydrophobic interactions. Glu81 interacts with the positively charged choline nitrogen of the phosphocholine. The existence of this hydrophobic pocket (lined by Glu81, Gly79, Asn61 and Thr76) would allow bindings of phosphocholine analogues, maybe with higher affinity. This property is very interesting for the research of new drugs blocking the effects of CRP, sometimes harmful. | - A hydrophobic pocket with the two key residues <scene name='56/568019/Phosphocholine/1'>Phe66 and Glu81</scene> located on the two extremities of the cavity. Phe66 interacts with the methyl group of the phosphocholine by hydrophobic interactions. Glu81 interacts with the positively charged choline nitrogen of the phosphocholine. The existence of this hydrophobic pocket (lined by Glu81, Gly79, Asn61 and Thr76) would allow bindings of phosphocholine analogues, maybe with higher affinity. This property is very interesting for the research of new drugs blocking the effects of CRP, sometimes harmful. | ||
- The two bound calcium ions which interact with the phosphate group of the phosphocholine (two oxygen of the phosphate group). | - The two bound calcium ions which interact with the phosphate group of the phosphocholine (two oxygen of the phosphate group). | ||
