Sandbox Reserved 813: Difference between revisions

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= Introduction =

~~Oct-4~~ [http://en.wikipedia.org/wiki/Oct-4] for Octamer–binding transcription factor 4, also known as POU5F1 ('''POU domain, class 5, transcription factor 1''') is a 352 amino acid protein encoded by the ''POU5F1'' gene. It is the earliest expressed gene known, and the gene is developmentally regulated during mammalian embryogenesis. The map position of oct 4 on mouse chromosome 17 is between Q and T region in the Major histocompatibility. The Oct-4 POU transcription factor is expressed in mammalian totipotent embryonic stem and germ cells. Oct-4 is the only factor that cannot be replace by an other factor of the POU family to induce pluripotency. His remplacement by a transcription factor cocktail does not lead to the successful derivation of induced pluripotent stem cells.

[http://en.wikipedia.org/wiki/Oct-4 Oct-4] for Octamer–binding transcription factor 4, also known as POU5F1 ('''POU domain, class 5, transcription factor 1''') is a 352 amino acid protein encoded by the ''POU5F1'' gene. It is the earliest expressed gene known, and the gene is developmentally regulated during mammalian embryogenesis. The map position of oct 4 on mouse chromosome 17 is between Q and T region in the Major histocompatibility. The Oct-4 POU transcription factor is expressed in mammalian totipotent embryonic stem and germ cells. Oct-4 is the only factor that cannot be replace by an other factor of the POU family to induce pluripotency. His remplacement by a transcription factor cocktail does not lead to the successful derivation of induced pluripotent stem cells.

POU (pronounced “pow”) transcription factor ( Pou stands for '''P'''it-1, '''O'''ct, '''U'''nc 86) are DNA–binding proteins that are able to activate the transcription of genes bearing cis acting elements containing an octamer motif ATGCAAAT. POU factors possess the capability to form homodimers to octamer motif variants and heterodimers with other POU members and also with members of the Sox family through the HMF ( DNA-binding) domain.

The POU domain is a bipartite domain present in all POU proteins. It consists of two subdomains, called the POU-specific domain and the POU homeodomain, connected by a flexible linker, variable in length.

Sandbox Reserved 813: Difference between revisions

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 {{STRUCTURE_3l1p| PDB=3l1p | SCENE= }}
 = Introduction =
-Oct-4 [http://en.wikipedia.org/wiki/Oct-4] for Octamer–binding transcription factor 4, also known as POU5F1 ('''POU domain, class 5, transcription factor 1''') is a 352 amino acid protein encoded by the ''POU5F1'' gene. It is the earliest expressed gene known, and the gene is developmentally regulated during mammalian embryogenesis. The map position of oct 4 on mouse chromosome 17 is between Q and T region in the Major histocompatibility. The Oct-4 POU transcription factor is expressed in mammalian totipotent embryonic stem and germ cells. Oct-4 is the only factor that cannot be replace by an other factor of the POU family  to induce pluripotency. His remplacement by a transcription factor cocktail does not lead to the successful derivation of induced pluripotent stem cells.
+[http://en.wikipedia.org/wiki/Oct-4 Oct-4] for Octamer–binding transcription factor 4, also known as POU5F1 ('''POU domain, class 5, transcription factor 1''') is a 352 amino acid protein encoded by the ''POU5F1'' gene. It is the earliest expressed gene known, and the gene is developmentally regulated during mammalian embryogenesis. The map position of oct 4 on mouse chromosome 17 is between Q and T region in the Major histocompatibility. The Oct-4 POU transcription factor is expressed in mammalian totipotent embryonic stem and germ cells. Oct-4 is the only factor that cannot be replace by an other factor of the POU family  to induce pluripotency. His remplacement by a transcription factor cocktail does not lead to the successful derivation of induced pluripotent stem cells.
 POU (pronounced “pow”) transcription factor ( Pou stands for '''P'''it-1, '''O'''ct, '''U'''nc 86) are DNA–binding proteins that are able to activate the transcription of genes bearing cis acting elements containing an octamer motif ATGCAAAT. POU factors possess the capability to form homodimers to octamer motif variants and heterodimers with other POU members and also with members of the Sox family through the HMF ( DNA-binding) domain.
 The POU domain is a bipartite domain present in all POU proteins. It consists of two subdomains, called the POU-specific domain and the POU homeodomain, connected by a flexible linker, variable in length.