2mj0: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Spatial structure of P33A mutant of non-conventional toxin WTX from Naja kaouthia==

~~The entry~~ 2mj0 is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[2mj0]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MJ0 FirstGlance]. <br>

~~Authors~~: ~~Paramonov~~, A.S., ~~Shenkarev~~, Z.O., Lyukmanova, E.N.

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mj0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mj0 RCSB], [http://www.ebi.ac.uk/pdbsum/2mj0 PDBsum]</span></td></tr>

</table>

~~Description~~: ~~Spatial structure of P33A mutant of non~~-conventional toxin ~~WTX from Naja kaouthia~~

== Function ==

[[http://www.uniprot.org/uniprot/TXWW_NAJKA TXWW_NAJKA]] Modulates both nicotinic and muscarinic acetylcholine receptors (nAChR and mAChR/CHRM). On nAChR, acts as an orthosteric (competitive) antagonist. On mAChR, in presence of ACh, it partially inhibits the effect of ACh (allosteric antagonist), whereas in the absence of ACh, it activates the receptor (allosteric agonist). Exerts a myorelaxant effect, induces a dose-dependent decrease in blood pressure and an increase in heart rate in mice and rats.<ref>PMID:11279130</ref> <ref>PMID:15581687</ref> <ref>PMID:17371532</ref> <ref>PMID:19682302</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Lyukmanova, E N]]

[[Category: Paramonov, A S]]

[[Category: Shenkarev, Z O]]

[[Category: Muscarinic acetylcholine receptor]]

[[Category: Nicotonic acetylcholine receptor]]

[[Category: Non-conventional toxin]]

[[Category: Toxin]]

[[Category: Weak toxin]]

[[Category: Wtx]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Spatial structure of P33A mutant of non-conventional toxin WTX from Naja kaouthia==
+<StructureSection load='2mj0' size='340' side='right' caption='[[2mj0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-The entry 2mj0 is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2mj0]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MJ0 FirstGlance]. <br>
-Authors: Paramonov, A.S., Shenkarev, Z.O., Lyukmanova, E.N.
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mj0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mj0 RCSB], [http://www.ebi.ac.uk/pdbsum/2mj0 PDBsum]</span></td></tr>
+</table>
-Description: Spatial structure of P33A mutant of non-conventional toxin WTX from Naja kaouthia
+== Function ==
+[[http://www.uniprot.org/uniprot/TXWW_NAJKA TXWW_NAJKA]] Modulates both nicotinic and muscarinic acetylcholine receptors (nAChR and mAChR/CHRM). On nAChR, acts as an orthosteric (competitive) antagonist. On mAChR, in presence of ACh, it partially inhibits the effect of ACh (allosteric antagonist), whereas in the absence of ACh, it activates the receptor (allosteric agonist). Exerts a myorelaxant effect, induces a dose-dependent decrease in blood pressure and an increase in heart rate in mice and rats.<ref>PMID:11279130</ref> <ref>PMID:15581687</ref> <ref>PMID:17371532</ref> <ref>PMID:19682302</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Lyukmanova, E N]]
+[[Category: Paramonov, A S]]
+[[Category: Shenkarev, Z O]]
+[[Category: Muscarinic acetylcholine receptor]]
+[[Category: Nicotonic acetylcholine receptor]]
+[[Category: Non-conventional toxin]]
+[[Category: Toxin]]
+[[Category: Weak toxin]]
+[[Category: Wtx]]