4j14: Difference between revisions
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{{STRUCTURE_4j14| PDB=4j14 | SCENE= }} | |||
===Crystal Structure of Human Cytochrome P450 CYP46A1 with Posaconazole Bound=== | |||
{{ABSTRACT_PUBMED_23604141}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CP46A_HUMAN CP46A_HUMAN]] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. | |||
==About this Structure== | |||
[[4j14]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J14 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023604141</ref><references group="xtra"/><references/> | |||
[[Category: Cholesterol 24-hydroxylase]] | |||
[[Category: Mast, N.]] | |||
[[Category: Pikuleva, I A.]] | |||
[[Category: Stout, C D.]] | |||
[[Category: Cholesterol 24-hydroxylase]] | |||
[[Category: Endoplasmic reticulum]] | |||
[[Category: Enzyme]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: P450]] | |||
[[Category: Posaconazole]] | |||
Revision as of 08:09, 15 January 2014
Crystal Structure of Human Cytochrome P450 CYP46A1 with Posaconazole Bound
Template:ABSTRACT PUBMED 23604141
Function
[CP46A_HUMAN] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.
About this Structure
4j14 is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Mast N, Zheng W, Stout CD, Pikuleva IA. Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1. Mol Pharmacol. 2013 Jul;84(1):86-94. doi: 10.1124/mol.113.085902. Epub 2013 Apr, 19. PMID:23604141 doi:https://dx.doi.org/10.1124/mol.113.085902
