4k1e: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR===

The ~~entry 4k1e~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[http://omim.org/entry/204700 204700]]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>

~~Authors~~: ~~Ilyichova, O~~.V.~~, Swedberg, J~~.~~E., de Veer, S~~.J., ~~Sit, K.C.~~, ~~Harris~~, J.~~M., Buckle, A.M~~.

==Function==

[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref> [[http://www.uniprot.org/uniprot/SFTI1_HELAN SFTI1_HELAN]] Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.<ref>PMID:10390350</ref>

~~Description~~: ~~Atomic resolution crystal structures of Kallikrein~~-~~Related Peptidase 4 complexed with a modified SFTI~~ inhibitor ~~FCQR~~

==About this Structure==

[[4k1e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1E OCA].

==Reference==

[[Category: Buckle, A M.]]

[[Category: Harris, J M.]]

[[Category: Ilyichova, O V.]]

[[Category: Sit, K C.]]

[[Category: Swedberg, J E.]]

[[Category: Veer, S J.de.]]

[[Category: Bowman-birk inhibitor]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

[[Category: Protease]]

[[Category: Protease inhibitor]]

[[Category: Protein-peptide complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4k1e|  PDB=4k1e  |  SCENE=  }}
+===Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR===
-The entry 4k1e is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[http://omim.org/entry/204700 204700]]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>
-Authors: Ilyichova, O.V., Swedberg, J.E., de Veer, S.J., Sit, K.C., Harris, J.M., Buckle, A.M.
+==Function==
+[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref>  [[http://www.uniprot.org/uniprot/SFTI1_HELAN SFTI1_HELAN]] Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.<ref>PMID:10390350</ref>
-Description: Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR
+==About this Structure==
+[[4k1e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1E OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Buckle, A M.]]
+[[Category: Harris, J M.]]
+[[Category: Ilyichova, O V.]]
+[[Category: Sit, K C.]]
+[[Category: Swedberg, J E.]]
+[[Category: Veer, S J.de.]]
+[[Category: Bowman-birk inhibitor]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Protease]]
+[[Category: Protease inhibitor]]
+[[Category: Protein-peptide complex]]