4mrt: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4mrt|  PDB=4mrt  |  SCENE=  }}
===Structure of the Phosphopantetheine Transferase Sfp in Complex with Coenzyme A and a Peptidyl Carrier Protein===
{{ABSTRACT_PUBMED_24704508}}


The entry 4mrt is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/TYCC_BREPA TYCC_BREPA]] Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product. [[http://www.uniprot.org/uniprot/SFP_BACSU SFP_BACSU]] Activates the seven peptidyl carrier protein (PCP) domains of surfactin synthase SRF1/2/3 by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue. Required for cells of B.subtilis to become producers of the lipopeptide antibiotics surfactin and plipastatin B1.<ref>PMID:8939709</ref>  


Authors: Tufar, P., Rahighi, S., Kraas, F.I., Kirchner, D.K., Loehr, F., Henrich, E., Koepke, J., Dikic, I., Guentert, P., Marahiel, M.A., Doetsch, V.
==About this Structure==
[[4mrt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRT OCA].  


Description: Structure of the Phosphopantetheine Transferase Sfp in Complex with Coenzyme A and a Peptidyl Carrier Protein
==Reference==
<ref group="xtra">PMID:024704508</ref><references group="xtra"/><references/>
[[Category: Dikic, I.]]
[[Category: Doetsch, V.]]
[[Category: Guentert, P.]]
[[Category: Henrich, E.]]
[[Category: Kirchner, D K.]]
[[Category: Koepke, J.]]
[[Category: Kraas, F I.]]
[[Category: Loehr, F.]]
[[Category: Marahiel, M A.]]
[[Category: Rahighi, S.]]
[[Category: Tufar, P.]]
[[Category: Pcp: aminoacyl/peptidyl carrier]]
[[Category: Sfp: coenzyme a binding]]
[[Category: Sfp: phosphopantetheine transferase]]
[[Category: Transport protein-transferase complex]]

Revision as of 07:45, 23 April 2014

Template:STRUCTURE 4mrt

Structure of the Phosphopantetheine Transferase Sfp in Complex with Coenzyme A and a Peptidyl Carrier Protein

Template:ABSTRACT PUBMED 24704508

Function

[TYCC_BREPA] Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product. [SFP_BACSU] Activates the seven peptidyl carrier protein (PCP) domains of surfactin synthase SRF1/2/3 by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue. Required for cells of B.subtilis to become producers of the lipopeptide antibiotics surfactin and plipastatin B1.[1]

About this Structure

4mrt is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. Tufar P, Rahighi S, Kraas FI, Kirchner DK, Lohr F, Henrich E, Kopke J, Dikic I, Guntert P, Marahiel MA, Dotsch V. Crystal Structure of a PCP/Sfp Complex Reveals the Structural Basis for Carrier Protein Posttranslational Modification. Chem Biol. 2014 Apr 2. pii: S1074-5521(14)00073-8. doi:, 10.1016/j.chembiol.2014.02.014. PMID:24704508 doi:https://dx.doi.org/10.1016/j.chembiol.2014.02.014
  1. ↑ Lambalot RH, Gehring AM, Flugel RS, Zuber P, LaCelle M, Marahiel MA, Reid R, Khosla C, Walsh CT. A new enzyme superfamily - the phosphopantetheinyl transferases. Chem Biol. 1996 Nov;3(11):923-36. PMID:8939709

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