4nre: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===The structure of human 15-lipoxygenase-2 with a substrate mimic===

~~The entry 4nre is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/LX15B_HUMAN LX15B_HUMAN]] Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophages differentiation into proatherogenic foam cells.<ref>PMID:11839751</ref> <ref>PMID:10625675</ref> <ref>PMID:12704195</ref> <ref>PMID:16112079</ref> <ref>PMID:18067895</ref> <ref>PMID:22912809</ref>

~~Authors~~: ~~Kobe, M.J., Neau, D.B., Mitchell, C.E., Bartlett, S~~.G.~~, Newcomer, M~~.E.

==About this Structure==

[[4nre]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRE OCA].

~~Description~~: ~~The structure of human 15-lipoxygenase-2 with a substrate mimic~~

==Reference==

[[Category: Bartlett, S G.]]

[[Category: Kobe, M J.]]

[[Category: Mitchell, C E.]]

[[Category: Neau, D B.]]

[[Category: Newcomer, M E.]]

[[Category: Calcium binding]]

[[Category: Oxidoreductase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4nre|  PDB=4nre  |  SCENE=  }}
+===The structure of human 15-lipoxygenase-2 with a substrate mimic===
-The entry 4nre is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/LX15B_HUMAN LX15B_HUMAN]] Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophages differentiation into proatherogenic foam cells.<ref>PMID:11839751</ref> <ref>PMID:10625675</ref> <ref>PMID:12704195</ref> <ref>PMID:16112079</ref> <ref>PMID:18067895</ref> <ref>PMID:22912809</ref>
-Authors: Kobe, M.J., Neau, D.B., Mitchell, C.E., Bartlett, S.G., Newcomer, M.E.
+==About this Structure==
+[[4nre]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRE OCA].
-Description: The structure of human 15-lipoxygenase-2 with a substrate mimic
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Bartlett, S G.]]
+[[Category: Kobe, M J.]]
+[[Category: Mitchell, C E.]]
+[[Category: Neau, D B.]]
+[[Category: Newcomer, M E.]]
+[[Category: Calcium binding]]
+[[Category: Oxidoreductase]]