Sandbox Reserved 822: Difference between revisions
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=== Binding site === | === Binding site === | ||
The binding site is formed by VL 1-3 which create a shallow, positively charged pocket at the open end of the β barrel. The structure was | The binding site is formed by VL 1-3 which create a shallow, positively charged pocket at the open end of the β barrel. The structure was determined from a crystal grown in the presence of Ins(1,3,4,5)P<sub>4</sub>, which is the head group of PtdIns(3,4,5)P<sub>3</sub>. The phosphoinositide-binding site is lined by positively charged residues which contact the phosphates of Ins(1,3,4,5)P<sub>4</sub> by forming up to 11 hydrogen bonds. <scene name='56/568020/Arg472/1'>Arg472</scene> forms two hydrogen bonds to the phosphate in the D1 position (D1-phosphate). | ||
== References == | == References == | ||
<references/> | <references/> | ||
