Sandbox Reserved 818: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Lea Clusan (talk | contribs) |
Lea Clusan (talk | contribs) |
||
| Line 13: | Line 13: | ||
==Binding of pertussis toxin to its cellular targets== | ==Binding of pertussis toxin to its cellular targets== | ||
After being secreted by the ''Ptl machinery'', a member of the [http://en.wikipedia.org/wiki/Secretion#Type_IV_secretion_system_.28T4SS_or_TFSS.29 type IV secretion system], pertussis toxin can interact with almost all mammalian cells, which explains the variety of biological activities of the toxin. <br /> | After being secreted by the ''Ptl machinery'', a member of the [http://en.wikipedia.org/wiki/Secretion#Type_IV_secretion_system_.28T4SS_or_TFSS.29 type IV secretion system], pertussis toxin can interact with almost all mammalian cells, which explains the variety of biological activities of the toxin. <br /> | ||
No specific receptors for PTX have been identified but many cell surface '''sialoglycoproteins''' are involved in the binding of PTX | No specific receptors for PTX have been identified but many cell surface [http://en.wikipedia.org/wiki/Sialoglycoprotein '''sialoglycoproteins'''] are involved in the binding of PTX | ||
<ref name="Peppler (1988)"> | <ref name="Peppler (1988)"> | ||
Armstrong,G. D.,Howard,L. A. & M S Peppler (1988) Use of glycosyltransferases to restore pertussis toxin receptor activity to asialoagalactofetuin. J. Biol. Chem., 263: 8677-8684. | Armstrong,G. D.,Howard,L. A. & M S Peppler (1988) Use of glycosyltransferases to restore pertussis toxin receptor activity to asialoagalactofetuin. J. Biol. Chem., 263: 8677-8684. | ||
