Sandbox Reserved 822: Difference between revisions
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== '''Structure''' == | == '''Structure''' == | ||
The structure 1W1H has in total 4 chains. These are represented by 1 sequence-unique entity. | The structure 1W1H has in total 4 chains. These are represented by 1 sequence-unique entity (for reasons of clarity all green links show therefore only one chain as a representation for all four chains). | ||
The PH domain of PDK1 reveals a structural variation of a standard PH domain fold with an additional 'bud' at the N-terminus. | The PH domain of PDK1 reveals a structural variation of a standard PH domain fold with an additional 'bud' at the N-terminus. | ||
[[Image:Topology_Diagram_of_PH_domain_of_PDK1.JPG|left|320px|thumb|Fig.1 Topology diagram of the PH domain of PDK1. The colors of the different sections correspond to the coloring of the Jmol structure applet. <ref> PMID: 524332 </ref>]] | |||
The standard PH domain fold consists of mainly three different sections: | The standard PH domain fold consists of mainly three different sections: | ||
*One section is a <scene name='56/568020/Barrel-like/3'>barrel-like structure</scene> formed by residues 456-530 | *One section is a <scene name='56/568020/Barrel-like/3'>barrel-like structure</scene> formed by residues 456-530. This structure is formed by two, almost orthogonal, β sheets, one consisting of four (β1 - β4) and one of three (β5 - β7) stand. | ||
*One side of the barrel is blocked by a <scene name='56/568020/Alpha1/1'>C-terminal alpha helix</scene>. | *One side of the barrel is blocked by a <scene name='56/568020/Alpha1/1'>C-terminal alpha helix</scene>. | ||
*On the other side of the barrel three variable loops (VL 1-3) form a bowl-like structure which is lined by positively charged residues, consituting the phosphoinositide-binding site. | *On the other side of the barrel three variable loops (VL 1-3) form a bowl-like structure which is lined by positively charged residues, consituting the phosphoinositide-binding site. | ||
