Sandbox Reserved 824: Difference between revisions
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The residues responsible for this interaction are localized in <scene name='56/568022/Hsrp54m_rna_bindv3/1'>helices 4, 5, 6 and 7</scene>, but most particularly in helices 5 and 6. | The residues responsible for this interaction are localized in <scene name='56/568022/Hsrp54m_rna_bindv3/1'>helices 4, 5, 6 and 7</scene>, but most particularly in helices 5 and 6. | ||
A large part of the top is therefore positively charged to bind with the negatively charged 7S RNA. | A large part of the top is therefore positively charged to bind with the negatively charged 7S RNA. | ||
[[Image:Proteopedia charge.png|300px|center|thumb| | [[Image:Proteopedia charge.png|300px|center|thumb| In the left side we can the SRP RNA part in blue, representing the positively charged part of SRP54M. See reference 1 for more details.]] | ||
It was also shown that the SRP54M - SRP RNA interaction is highly dependent of the structural integrity of the <scene name='56/568022/Hsrp54m_core_and_h1/1'>SRP54M Core structure</scene>. | It was also shown that the SRP54M - SRP RNA interaction is highly dependent of the structural integrity of the <scene name='56/568022/Hsrp54m_core_and_h1/1'>SRP54M Core structure</scene>. | ||
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[[1mfq]] – hSRP19 + hSRP54 M domain + 7S RNA S domain | [[1mfq]] – hSRP19 + hSRP54 M domain + 7S RNA S domain | ||
== | ==References== | ||
# Clemons, W M, Jr, K Gowda, S D Black, C Zwieb, and V Ramakrishnan. “Crystal Structure of the Conserved Subdomain of Human Protein SRP54M at 2.1 A Resolution: Evidence for the Mechanism of Signal Peptide Binding.” Journal of Molecular Biology 292, no. 3 (September 24, 1999): 697–705. doi:10.1006/jmbi.1999.3090. | # Clemons, W M, Jr, K Gowda, S D Black, C Zwieb, and V Ramakrishnan. “Crystal Structure of the Conserved Subdomain of Human Protein SRP54M at 2.1 A Resolution: Evidence for the Mechanism of Signal Peptide Binding.” Journal of Molecular Biology 292, no. 3 (September 24, 1999): 697–705. doi:10.1006/jmbi.1999.3090. | ||
# Halic, Mario, Thomas Becker, Martin R. Pool, Christian M. T. Spahn, Robert A. Grassucci, Joachim Frank, and Roland Beckmann. “Structure of the Signal Recognition Particle Interacting with the Elongation-Arrested Ribosome.” Nature 427, no. 6977 (February 26, 2004): 808–814. doi:10.1038/nature02342. | # Halic, Mario, Thomas Becker, Martin R. Pool, Christian M. T. Spahn, Robert A. Grassucci, Joachim Frank, and Roland Beckmann. “Structure of the Signal Recognition Particle Interacting with the Elongation-Arrested Ribosome.” Nature 427, no. 6977 (February 26, 2004): 808–814. doi:10.1038/nature02342. | ||
# Huang, Qiaojia, Sayran Abdulrahman, Jiaming Yin, and Christian Zwieb. “Systematic Site-Directed Mutagenesis of Human Protein SRP54: Interactions with Signal Recognition Particle RNA and Modes of Signal Peptide Recognition.” Biochemistry 41, no. 38 (September 24, 2002): 11362–11371. | # Huang, Qiaojia, Sayran Abdulrahman, Jiaming Yin, and Christian Zwieb. “Systematic Site-Directed Mutagenesis of Human Protein SRP54: Interactions with Signal Recognition Particle RNA and Modes of Signal Peptide Recognition.” Biochemistry 41, no. 38 (September 24, 2002): 11362–11371. | ||
==Contributors== | ==Contributors== | ||
Gregoire de Claviere and Hamelin Baptiste</StructureSection><!-- PLEASE DO NOT DELETE THIS TEMPLATE --> | |||
{{Sandbox_Reserved_ESBS}} | {{Sandbox_Reserved_ESBS}} | ||
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