Sandbox Reserved 818: Difference between revisions
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. The N-terminal regions of these subunits are involved in receptor binding and the C-terminal domains of S2 and S3 adopt a fold found in other carbohydrate-binding proteins [73]. <br /> | . The N-terminal regions of these subunits are involved in receptor binding and the C-terminal domains of S2 and S3 adopt a fold found in other carbohydrate-binding proteins [73]. <br /> | ||
The B oligomer of PTX is involved in some biological activities of the toxin, independently of the enzyme activity. Thus <scene name='56/568016/Ptx_asn105/1'>Asn105</scene> in ''S2'' and '' | The B oligomer of PTX is involved in some biological activities of the toxin, independently of the enzyme activity. Thus <scene name='56/568016/Ptx_asn105/1'>Asn105</scene> in ''S2'' and <scene name='56/568016/Ptx_lys105/1'>Lys105</scene> in ''S3'' are important for the mitogenic activity of pertussis toxin on murine T lymphocytes | ||
<ref name="Locht93"> | <ref name="Locht93"> | ||
Lobet, Y., Feron, C., Dequesne, G., Simoen, E., Hauser, P., & Locht, C. (1993). Site-specific alterations in the B oligomer that affect receptor-binding activities and mitogenicity of pertussis toxin. The Journal of experimental medicine, 177(1), 79-87. | Lobet, Y., Feron, C., Dequesne, G., Simoen, E., Hauser, P., & Locht, C. (1993). Site-specific alterations in the B oligomer that affect receptor-binding activities and mitogenicity of pertussis toxin. The Journal of experimental medicine, 177(1), 79-87. | ||
