Sandbox Reserved 815: Difference between revisions
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The protein exists in majority in its dimer form. | The protein exists in majority in its dimer form. | ||
Between each helix 144-156 of the two proteins, it exists many interactions whose stabilize the dimer interface. It can be retain acidic and mostly negative residues, or basic and positive residues. | Between each helix 144-156 of the two proteins, it exists many interactions whose stabilize the dimer interface. It can be retain acidic and mostly negative residues, or basic and positive residues. | ||
Each helix 171−188 is linked to the C-terminal helix 200−225 of the other monomer. Van der Waals forces are here between such nonpolar residues as valine, isoleucine, and nonpolar sections as histadine, methionine, and glutamic acid. | Each helix 171−188 is linked to the C-terminal helix 200−225 of the other monomer. [http://en.wikipedia.org/wiki/Van_der_Waals_forces Van der Waals] forces are here between such nonpolar residues as valine, isoleucine, and nonpolar sections as histadine, methionine, and glutamic acid. | ||
It occurs hydrogen bonding between the dimers at Thr188 O−Gly195 N, Thr190 O−Lys194 N and Thr192 O−Thr192 N | It occurs hydrogen bonding between the dimers at Thr188 O−Gly195 N, Thr190 O−Lys194 N and Thr192 O−Thr192 N | ||
On each monomer, a hydrogen bond between Asp 202 and Thr 199 stabilize the dimeric structure. | On each monomer, a hydrogen bond between Asp 202 and Thr 199 stabilize the dimeric structure. | ||
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In fact, the 3haf domain is only one chain with 2 binding sites for residues CD (H40 and D147)and 1 binding domains for CL S132. | In fact, the 3haf domain is only one chain with 2 binding sites for residues CD (H40 and D147)and 1 binding domains for CL S132. | ||
The entire 3HAF domain can interact with Growth factor receptor-bound protein 2 (GRB2), exoribonuclease 3(ERI3) and Synapsin I (SYN1). There are 3 types of non-polymeric entities that can bind this domain:cadmium ion, chloride ion, water. | The entire 3HAF domain can interact with [http://en.wikipedia.org/wiki/GRB2 Growth factor receptor-bound protein 2] (GRB2), [http://en.wikipedia.org/wiki/Exoribonuclease exoribonuclease 3](ERI3) and [http://en.wikipedia.org/wiki/Synapsin_I Synapsin I] (SYN1). There are 3 types of non-polymeric entities that can bind this domain:cadmium ion, chloride ion, water. | ||
For this domain, two glycosylated sites exist on helix 2 and 3 at Asn181 and Asn197. | For this domain, two glycosylated sites exist on helix 2 and 3 at Asn181 and Asn197. | ||
