DNA ligase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 26: | Line 26: | ||
'''DNA ligase''' (LigD) is an enzyme which repairs single-stranded breaks in a double-stranded DNA. LigD is activated , in a species-dependent manner, by hydrolysis of ATP or NAD+. Mammalian LigD I ligates the nascent DNA of the lagging strand; LigD III complexes with XRCC1 in the process of nucleotide excision repair; LigD IV complexes with XRCC4 and catalyzes the last step in the non-homologous DNA end joining.LigD contains several domains: adenylation domain; DNA-binding domain and the ca. 100 amino acid long BRCT motif. See more details in [[ATP-Dependent DNA Ligase (Bacteriophage T7) | '''DNA ligase''' (LigD) is an enzyme which repairs single-stranded breaks in a double-stranded DNA. LigD is activated , in a species-dependent manner, by hydrolysis of ATP or NAD+. Mammalian LigD I ligates the nascent DNA of the lagging strand; LigD III complexes with XRCC1 in the process of nucleotide excision repair; LigD IV complexes with XRCC4 and catalyzes the last step in the non-homologous DNA end joining. LigD contains several domains: adenylation domain; DNA-binding domain and the ca. 100 amino acid long BRCT motif. See more details in [[ATP-Dependent DNA Ligase (Bacteriophage T7)]]. | ||
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
