Sandbox Reserved 830: Difference between revisions
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Activation of those pathways stimulates several responses. The main one is proliferation of a lot of different cell lines by increasing production of molecules, such as proliferation factors and metalloproteinase inhibitors. In endothelial cells, vascular endothelial growth factors (VEGF) are secreted, promoting angiogenesis. Binding of OSM induces inhibition of other cell proliferation, like stem cells or tumor cells, by blocking the cell cycle in G2/M<ref name="three"> PMID: 10446061 </ref>. Binding of OSM grant an invasive phenotype of cells by stimulation of chemokine secretion (like eotaxin). Chemokine allows activation of immune cells as well, and then stimulates the production of antibodies<ref name="two"> PMID: 24381786 </ref>. Physiological function of OSM in the central nervous system remains unknown<ref group=""> PMID: 14985435 </ref>. | Activation of those pathways stimulates several responses. The main one is proliferation of a lot of different cell lines by increasing production of molecules, such as proliferation factors and metalloproteinase inhibitors. In endothelial cells, vascular endothelial growth factors (VEGF) are secreted, promoting angiogenesis. Binding of OSM induces inhibition of other cell proliferation, like stem cells or tumor cells, by blocking the cell cycle in G2/M<ref name="three"> PMID: 10446061 </ref>. Binding of OSM grant an invasive phenotype of cells by stimulation of chemokine secretion (like eotaxin). Chemokine allows activation of immune cells as well, and then stimulates the production of antibodies<ref name="two"> PMID: 24381786 </ref>. Physiological function of OSM in the central nervous system remains unknown<ref group=""> PMID: 14985435 </ref>. | ||
==Disease== | ==Disease== | ||
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Epigenetic mutations, such as methylation, cause the silencing of OSMR, thus the inhibition of both colon cancer cell lines and papillary thyroid cancer cell proliferation<ref name="two"> PMID: 24381786 </ref>. | Epigenetic mutations, such as methylation, cause the silencing of OSMR, thus the inhibition of both colon cancer cell lines and papillary thyroid cancer cell proliferation<ref name="two"> PMID: 24381786 </ref>. | ||
==References== | ==References== | ||
