Sandbox Reserved 830: Difference between revisions

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Activation of those pathways stimulates several responses. The main one is proliferation of a lot of different cell lines by increasing production of molecules, such as proliferation factors and metalloproteinase inhibitors. In endothelial cells, vascular endothelial growth factors (VEGF) are secreted, promoting angiogenesis. Binding of OSM induces inhibition of other cell proliferation, like stem cells or tumor cells, by blocking the cell cycle in G2/M<ref name="three"> PMID: 10446061 </ref>. Binding of OSM ~~grant~~ an invasive phenotype of cells by stimulation of chemokine secretion (like eotaxin). Chemokine allows activation of immune cells as well, and then stimulates the production of antibodies<ref name="two"> PMID: 24381786 </ref>. Physiological function of OSM in the central nervous system remains unknown<ref group=""> PMID: 14985435 </ref>.

Activation of those pathways stimulates several responses. The main one is proliferation of a lot of different cell lines by increasing production of molecules, such as proliferation factors and metalloproteinase inhibitors. In endothelial cells, vascular endothelial growth factors (VEGF) are secreted, promoting angiogenesis. Binding of OSM induces inhibition of other cell proliferation, like stem cells or tumor cells, by blocking the cell cycle in G2/M<ref name="three"> PMID: 10446061 </ref>. Binding of OSM grants an invasive phenotype to cells by stimulation of chemokine secretion (like eotaxin). Chemokine allows activation of immune cells as well, and then stimulates the production of antibodies<ref name="two"> PMID: 24381786 </ref>. Physiological function of OSM in the central nervous system remains unknown<ref group=""> PMID: 14985435 </ref>.

Sandbox Reserved 830: Difference between revisions

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Revision as of 17:58, 9 January 2014 view source Pierre-Yves Mocaer (talk \| contribs) 210 edits No edit summary ← Older edit		Revision as of 18:00, 9 January 2014 view source Pierre-Yves Mocaer (talk \| contribs) 210 edits No edit summary Newer edit →
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	Activation of those pathways stimulates several responses. The main one is proliferation of a lot of different cell lines by increasing production of molecules, such as proliferation factors and metalloproteinase inhibitors. In endothelial cells, vascular endothelial growth factors (VEGF) are secreted, promoting angiogenesis. Binding of OSM induces inhibition of other cell proliferation, like stem cells or tumor cells, by blocking the cell cycle in G2/M<ref name="three"> PMID: 10446061 </ref>. Binding of OSM ~~grant~~ an invasive phenotype of cells by stimulation of chemokine secretion (like eotaxin). Chemokine allows activation of immune cells as well, and then stimulates the production of antibodies<ref name="two"> PMID: 24381786 </ref>. Physiological function of OSM in the central nervous system remains unknown<ref group=""> PMID: 14985435 </ref>.		Activation of those pathways stimulates several responses. The main one is proliferation of a lot of different cell lines by increasing production of molecules, such as proliferation factors and metalloproteinase inhibitors. In endothelial cells, vascular endothelial growth factors (VEGF) are secreted, promoting angiogenesis. Binding of OSM induces inhibition of other cell proliferation, like stem cells or tumor cells, by blocking the cell cycle in G2/M<ref name="three"> PMID: 10446061 </ref>. Binding of OSM grants an invasive phenotype to cells by stimulation of chemokine secretion (like eotaxin). Chemokine allows activation of immune cells as well, and then stimulates the production of antibodies<ref name="two"> PMID: 24381786 </ref>. Physiological function of OSM in the central nervous system remains unknown<ref group=""> PMID: 14985435 </ref>.