4n5b: Difference between revisions

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{{STRUCTURE_4n5b|  PDB=4n5b  |  SCENE=  }}
===Crystal structure of the Nipah virus phosphoprotein tetramerization domain===
{{ABSTRACT_PUBMED_24155387}}


==About this Structure==
==Crystal structure of the Nipah virus phosphoprotein tetramerization domain==
[[4n5b]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Nipav Nipav]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5B OCA].  
<StructureSection load='4n5b' size='340' side='right'caption='[[4n5b]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4n5b]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Nipah_henipavirus Nipah henipavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N5B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n5b OCA], [https://pdbe.org/4n5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n5b RCSB], [https://www.ebi.ac.uk/pdbsum/4n5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n5b ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/D2DEB8_NIPAV D2DEB8_NIPAV]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Nipah virus phosphoprotein, P, is multimeric and tethers the viral polymerase to the nucleocapsid. We present the crystal structure of the multimerization domain of Nipah P: a long, parallel, tetrameric, coiled coil with a small, alpha-helical cap structure. Across the paramyxoviruses, these domains share little sequence identity; yet retain similar length and structural organization, suggesting a common requirement for scaffolding or spatial organization of the functions of P in the virus life cycle.


==Reference==
Crystal structure of the Nipah virus phosphoprotein tetramerization domain.,Bruhn-Johannsen JF, Barnett K, Bibby J, Thomas J, Keegan R, Rigden D, Bornholdt ZA, Saphire EO J Virol. 2013 Oct 23. PMID:24155387<ref>PMID:24155387</ref>
<ref group="xtra">PMID:024155387</ref><references group="xtra"/><references/>
 
[[Category: Nipav]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Barnett, K.]]
</div>
[[Category: Bibby, J.]]
<div class="pdbe-citations 4n5b" style="background-color:#fffaf0;"></div>
[[Category: Bornholdt, Z A.]]
== References ==
[[Category: Bruhn, J F.]]
<references/>
[[Category: Keegan, R.]]
__TOC__
[[Category: Rigden, D.]]
</StructureSection>
[[Category: Saphire, E O.]]
[[Category: Large Structures]]
[[Category: Thomas, J.]]
[[Category: Nipah henipavirus]]
[[Category: Interferon inhibitor]]
[[Category: Barnett K]]
[[Category: Nucleoprotein chaperone]]
[[Category: Bibby J]]
[[Category: Viral polymerase co-factor]]
[[Category: Bornholdt ZA]]
[[Category: Viral protein]]
[[Category: Bruhn JF]]
[[Category: Keegan R]]
[[Category: Rigden D]]
[[Category: Saphire EO]]
[[Category: Thomas J]]
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