4c47: Difference between revisions
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==Salmonella enterica trimeric lipoprotein SadB== | |||
=== | <StructureSection load='4c47' size='340' side='right' caption='[[4c47]], [[Resolution|resolution]] 2.45Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4c47]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C47 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C47 FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c46|4c46]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c47 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c47 RCSB], [http://www.ebi.ac.uk/pdbsum/4c47 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Trimeric Autotransporter Adhesins (TAAs) are important virulence factors of many gram-negative bacterial pathogens. TAAs form fibrous, adhesive structures on the bacterial cell surface. Their N-terminal, extracellular domains are exported through a C-terminal membrane pore; the insertion of the pore domain into the bacterial outer membrane follows the rules of beta-barrel transmembrane protein biogenesis and is dependent on the essential Bam complex. We have recently described the full fiber structure of SadA, a TAA of unknown function in Salmonella and other enterobacteria. In this work, we describe the structure and function of SadB, a small inner membrane lipoprotein. The sadB gene is located in an operon with sadA; orthologous operons are only found in enterobacteria, while other TAAs are not typically associated with lipoproteins. Strikingly, SadB is also a trimer, and its co-expression with SadA has a direct influence on SadA structural integrity. This is the first report of a specific export factor of a TAA, suggesting that at least in some cases, TAA autotransport is assisted by additional periplasmic proteins. | |||
A Trimeric Lipoprotein assists in Trimeric Autotransporter Biogenesis in Enterobacteria.,Grin I, Hartmann MD, Sauer G, Hernandez Alvarez B, Schutz M, Madlung J, Macek B, Felipe-Lopez A, Hensel M, Lupas A, Linke D J Biol Chem. 2013 Dec 25. PMID:24369174<ref>PMID:24369174</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
[[Category: Grin, I | == References == | ||
[[Category: Hartmann, M D | <references/> | ||
[[Category: Linke, D | __TOC__ | ||
</StructureSection> | |||
[[Category: Salty]] | |||
[[Category: Grin, I]] | |||
[[Category: Hartmann, M D]] | |||
[[Category: Linke, D]] | |||
[[Category: Autotransport]] | [[Category: Autotransport]] | ||
[[Category: Bacterial adhesion]] | [[Category: Bacterial adhesion]] | ||
