2m7d: Difference between revisions
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==Trp-cage 16b P12W: a Hyperstable Miniprotein== | |||
=== | <StructureSection load='2m7d' size='340' side='right' caption='[[2m7d]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2m7d]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M7D FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2m7c|2m7c]], [[2jof|2jof]], [[1l2y|1l2y]], [[1rij|1rij]], [[2ldj|2ldj]], [[2ll5|2ll5]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m7d RCSB], [http://www.ebi.ac.uk/pdbsum/2m7d PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The Trp-cage, at 20 residues in length, is generally acknowledged as the smallest fully protein-like folding motif. Linking the termini by a two-residue unit and excising one residue affords circularly permuted sequences that adopt the same structure. This represents the first successful circular permutation of any fold of less than 50-residue length. As was observed for the original topology, a hydrophobic staple near the chain termini is required for enhanced fold stability. | |||
Circular Permutation of the Trp-cage: Fold Rescue upon Addition of a Hydrophobic Staple.,Byrne A, Kier BL, Williams DV, Scian M, Andersen NH RSC Adv. 2013 Nov 21;2013(43). doi: 10.1039/C3RA43674H. PMID:24376912<ref>PMID:24376912</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
[[Category: Andersen, N H | == References == | ||
[[Category: Kier, B L | <references/> | ||
[[Category: Williams, D V | __TOC__ | ||
</StructureSection> | |||
[[Category: Andersen, N H]] | |||
[[Category: Kier, B L]] | |||
[[Category: Williams, D V]] | |||
[[Category: Circular permutant]] | [[Category: Circular permutant]] | ||
[[Category: De novo protein]] | [[Category: De novo protein]] | ||
Revision as of 17:55, 19 January 2015
Trp-cage 16b P12W: a Hyperstable Miniprotein
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