4c0o: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Transportin 3 in complex with phosphorylated ASF/SF2===

~~The entry 4c0o is ON HOLD~~ ~~until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/TNPO3_HUMAN TNPO3_HUMAN]] Primary biliary cirrhosis;Autosomal dominant limb-girdle muscular dystrophy type 1F.

~~Authors~~: ~~Maertens~~, G., ~~Cook~~, N., ~~Cherepanov~~, P.

==Function==

[[http://www.uniprot.org/uniprot/TNPO3_HUMAN TNPO3_HUMAN]] Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains.<ref>PMID:10366588</ref> <ref>PMID:10713112</ref> <ref>PMID:11517331</ref> <ref>PMID:12628928</ref> [[http://www.uniprot.org/uniprot/SRSF1_HUMAN SRSF1_HUMAN]] Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors.<ref>PMID:8223481</ref> <ref>PMID:8139654</ref>

~~Description~~: ~~Transportin 3 in~~ complex ~~with phosphorylated SFRS1~~

==About this Structure==

[[4c0o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0O OCA].

==Reference==

[[Category: Cherepanov, P.]]

[[Category: Cook, N.]]

[[Category: Maertens, G.]]

[[Category: Heat repeat]]

[[Category: Nuclear import]]

[[Category: Rrm domain]]

[[Category: Rs domain]]

[[Category: Splicing factor]]

[[Category: Transport protein-rna binding protein complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4c0o|  PDB=4c0o  |  SCENE=  }}
+===Transportin 3 in complex with phosphorylated ASF/SF2===
-The entry 4c0o is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/TNPO3_HUMAN TNPO3_HUMAN]] Primary biliary cirrhosis;Autosomal dominant limb-girdle muscular dystrophy type 1F.
-Authors: Maertens, G., Cook, N., Cherepanov, P.
+==Function==
+[[http://www.uniprot.org/uniprot/TNPO3_HUMAN TNPO3_HUMAN]] Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains.<ref>PMID:10366588</ref> <ref>PMID:10713112</ref> <ref>PMID:11517331</ref> <ref>PMID:12628928</ref>  [[http://www.uniprot.org/uniprot/SRSF1_HUMAN SRSF1_HUMAN]] Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors.<ref>PMID:8223481</ref> <ref>PMID:8139654</ref>
-Description: Transportin 3 in complex with phosphorylated SFRS1
+==About this Structure==
+[[4c0o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0O OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Cherepanov, P.]]
+[[Category: Cook, N.]]
+[[Category: Maertens, G.]]
+[[Category: Heat repeat]]
+[[Category: Nuclear import]]
+[[Category: Rrm domain]]
+[[Category: Rs domain]]
+[[Category: Splicing factor]]
+[[Category: Transport protein-rna binding protein complex]]