4civ: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4civ|  PDB=4civ  |  SCENE=  }}
===Crystal structure of Mycobacterium tuberculosis type 2 dehydroquinase in complex with (1R,4R,5R)-1,4,5-trihydroxy-3-hydroxymethylcyclohex-2-ene-1-carboxylic acid===
{{ABSTRACT_PUBMED_24689821}}


The entry 4civ is ON HOLD  until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]


Authors: Otero, J.M., Llamas-Saiz, A.L., Lamb, H., Hawkins, A.R., Blanco, B., Sedes, A., Peon, A., Gonzalez-Bello, C., vanRaaij, M.J.
==About this Structure==
[[4civ]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CIV OCA].  


Description: Crystal structure of Mycobacterium tuberculosis type 2 dehydroquinase in complex with (1R,4R,5R)-1,4,5-trihydroxy-3-hydroxymethylcyclohex-2-ene-1-carboxylic acid
==Reference==
<ref group="xtra">PMID:024689821</ref><references group="xtra"/><references/>
[[Category: 3-dehydroquinate dehydratase]]
[[Category: Blanco, B.]]
[[Category: Gonzalez-Bello, C.]]
[[Category: Hawkins, A R.]]
[[Category: Lamb, H.]]
[[Category: Llamas-Saiz, A L.]]
[[Category: Otero, J M.]]
[[Category: Peon, A.]]
[[Category: Sedes, A.]]
[[Category: VanRaaij, M J.]]
[[Category: Bacterial protein]]
[[Category: Inhibitor]]
[[Category: Lyase]]
[[Category: Protein binding]]
[[Category: Shikimis acid pathway]]
[[Category: Substrate specificity]]

Revision as of 09:42, 16 April 2014

Template:STRUCTURE 4civ

Crystal structure of Mycobacterium tuberculosis type 2 dehydroquinase in complex with (1R,4R,5R)-1,4,5-trihydroxy-3-hydroxymethylcyclohex-2-ene-1-carboxylic acid

Template:ABSTRACT PUBMED 24689821

Function

[AROQ_MYCTU] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]

About this Structure

4civ is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. Blanco B, Sedes A, Peon A, Otero JM, Raaij MJ, Thompson P, Hawkins AR, Gonzalez-Bello C. Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors. J Med Chem. 2014 Apr 1. PMID:24689821 doi:https://dx.doi.org/10.1021/jm500175z

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