4ng6: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates==

~~The entry~~ 4ng6 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4ng6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NG6 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NG6 FirstGlance].

~~Authors~~: ~~Tsoumpra~~, M.K., ~~Muniz~~, J.R.C., Barnett, B.L~~., Pilka~~, E., ~~Kwaasi~~, A~~.A.,~~ Kavanagh, K.L~~., Evdokimov~~, A~~., Walter~~, R.~~L., Ebetino, F.H.,~~ Oppermann, U., Russell, R.G.G., ~~Dunford~~, ~~J.E.~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=IPE:3-METHYLBUT-3-ENYL+TRIHYDROGEN+DIPHOSPHATE'>IPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4kfa|4kfa]], [[4kqs|4kqs]], [[1yq7|1yq7]]</td></tr>

~~Description~~: ~~The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ng6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ng6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ng6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ng6 PDBsum]</td></tr>

</table>

__TOC__

</StructureSection>

[[Category: Barnett, B L]]

[[Category: Dunford, J E]]

[[Category: Ebetino, F H]]

[[Category: Evdokimov, A]]

[[Category: Kavanagh, K L]]

[[Category: Kwaasi, A A]]

[[Category: Muniz, J R.C]]

[[Category: Oppermann, U]]

[[Category: Pilka, E]]

[[Category: Russell, R G.G]]

[[Category: Tsoumpra, M K]]

[[Category: Walter, R L]]

[[Category: Alpha-helical prenyltransferase]]

[[Category: Bisphosphonate]]

[[Category: Cholesterol synthesis]]

[[Category: Isoprene biosynthesis]]

[[Category: Isoprenoid pathway]]

[[Category: Lipid synthesis]]

[[Category: Steroid biosynthesis]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates==
+<StructureSection load='4ng6' size='340' side='right' caption='[[4ng6]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-The entry 4ng6 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ng6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NG6 FirstGlance]. <br>
-Authors: Tsoumpra, M.K., Muniz, J.R.C., Barnett, B.L., Pilka, E., Kwaasi, A.A., Kavanagh, K.L., Evdokimov, A., Walter, R.L., Ebetino, F.H., Oppermann, U., Russell, R.G.G., Dunford, J.E.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPE:3-METHYLBUT-3-ENYL+TRIHYDROGEN+DIPHOSPHATE'>IPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kfa|4kfa]], [[4kqs|4kqs]], [[1yq7|1yq7]]</td></tr>
-Description: The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ng6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ng6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ng6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ng6 PDBsum]</span></td></tr>
+</table>
+__TOC__
+</StructureSection>
+[[Category: Barnett, B L]]
+[[Category: Dunford, J E]]
+[[Category: Ebetino, F H]]
+[[Category: Evdokimov, A]]
+[[Category: Kavanagh, K L]]
+[[Category: Kwaasi, A A]]
+[[Category: Muniz, J R.C]]
+[[Category: Oppermann, U]]
+[[Category: Pilka, E]]
+[[Category: Russell, R G.G]]
+[[Category: Tsoumpra, M K]]
+[[Category: Walter, R L]]
+[[Category: Alpha-helical prenyltransferase]]
+[[Category: Bisphosphonate]]
+[[Category: Cholesterol synthesis]]
+[[Category: Isoprene biosynthesis]]
+[[Category: Isoprenoid pathway]]
+[[Category: Lipid synthesis]]
+[[Category: Steroid biosynthesis]]
+[[Category: Transferase]]