4o68: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4o68|  PDB=4o68  |  SCENE=  }}
+===Structure of human cyclic GMP-AMP synthase (cGAS)===
-The entry 4o68 is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>
-Authors: Zhang, X., Chen, Z., Zhang, X.W., Chen, Z.J.
+==About this Structure==
+[[4o68]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O68 OCA].
-Description:
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Cyclic GMP-AMP synthase]]
+[[Category: Chen, Z.]]
+[[Category: Chen, Z J.]]
+[[Category: Zhang, X.]]
+[[Category: Zhang, X W.]]
+[[Category: Immune response]]
+[[Category: Transferase]]

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