2miu: Difference between revisions

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~~{{STRUCTURE_2miu| PDB=2miu | SCENE= }}~~

==Structure of FHL2 LIM adaptor and its Interaction with Ski==

===Structure of FHL2 LIM adaptor and its Interaction with Ski===

== Structural highlights ==

==~~Function~~==

<table><tr><td colspan='2'>[[2miu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIU OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIU FirstGlance].

[[http://~~www~~.~~uniprot~~.org/~~uniprot~~/~~FHL2_HUMAN FHL2_HUMAN~~]] ~~May function as~~ a ~~molecular transmitter linking various signaling pathways to transcriptional regulation~~. ~~Negatively regulates the transcriptional repressor E4F1 and may function in cell growth~~. ~~Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation~~.<~~ref~~>~~PMID~~:~~15692560~~</~~ref~~> <~~ref~~>~~PMID~~:~~16652157~~</~~ref~~> <~~ref~~>~~PMID~~:~~18853468~~</~~ref~~>

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">FHL2, DRAL, SLIM3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

==~~About this Structure~~==

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2miu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2miu RCSB], [http://www.ebi.ac.uk/pdbsum/2miu PDBsum]</td></tr>

[[2miu]~~] is a 1 chain structure. Full experimental information is available from~~ [http://oca.weizmann.ac.il/oca-bin/~~ocashort~~?id=~~2MIU~~ OCA].

</table>

__TOC__

~~==Reference=~~=

</StructureSection>

<~~references group="xtra"~~/><~~references~~/>

[[Category: Human]]

[[Category: Medrano, E E.]]

[[Category: Medrano, E E]]

[[Category: Sun, Y.]]

[[Category: Sun, Y]]

[[Category: Tian, X.]]

[[Category: Tian, X]]

[[Category: Weiss, M A.]]

[[Category: Weiss, M A]]

[[Category: Yang, Y.]]

[[Category: Yang, Y]]

[[Category: Fhl2]]

[[Category: Lim domain]]

[[Category: Protein binding]]

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-{{STRUCTURE_2miu|  PDB=2miu  |  SCENE=  }}
+==Structure of FHL2 LIM adaptor and its Interaction with Ski==
-===Structure of FHL2 LIM adaptor and its Interaction with Ski===
+<StructureSection load='2miu' size='340' side='right' caption='[[2miu]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+== Structural highlights ==
-==Function==
+<table><tr><td colspan='2'>[[2miu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIU FirstGlance]. <br>
-[[http://www.uniprot.org/uniprot/FHL2_HUMAN FHL2_HUMAN]] May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.<ref>PMID:15692560</ref> <ref>PMID:16652157</ref> <ref>PMID:18853468</ref>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FHL2, DRAL, SLIM3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2miu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2miu RCSB], [http://www.ebi.ac.uk/pdbsum/2miu PDBsum]</span></td></tr>
-[[2miu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIU OCA].
+</table>
+__TOC__
-==Reference==
+</StructureSection>
-<references group="xtra"/><references/>
+[[Category: Human]]
-[[Category: Medrano, E E.]]
+[[Category: Medrano, E E]]
-[[Category: Sun, Y.]]
+[[Category: Sun, Y]]
-[[Category: Tian, X.]]
+[[Category: Tian, X]]
-[[Category: Weiss, M A.]]
+[[Category: Weiss, M A]]
-[[Category: Yang, Y.]]
+[[Category: Yang, Y]]
 [[Category: Fhl2]]
 [[Category: Lim domain]]
 [[Category: Protein binding]]