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{{STRUCTURE_4irv|  PDB=4irv  |  SCENE=  }}
==Structure of the Helicobacter pylori CagA Oncogene Bound to the Human Tumor Suppressor Apoptosis-stimulating Protein of p53-2==
===Structure of the Helicobacter pylori CagA Oncogene Bound to the Human Tumor Suppressor Apoptosis-stimulating Protein of p53-2===
<StructureSection load='4irv' size='340' side='right' caption='[[4irv]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4irv]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IRV FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/CAGA_HELPY CAGA_HELPY]] May be necessary for the transcription, folding, export, or function of the cytotoxin. [[http://www.uniprot.org/uniprot/ASPP2_HUMAN ASPP2_HUMAN]] Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.<ref>PMID:11684014</ref> <ref>PMID:12694406</ref> <ref>PMID:19377511</ref>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
 
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cagA, cag26, cai, HP_0547 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85962 Campylobacter pylori]), ASPP2, BBP, TP53BP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4irv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4irv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4irv RCSB], [http://www.ebi.ac.uk/pdbsum/4irv PDBsum]</span></td></tr>
[[4irv]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IRV OCA].  
</table>
 
__TOC__
==Reference==
</StructureSection>
<references group="xtra"/><references/>
[[Category: Campylobacter pylori]]
[[Category: Nesic, D.]]
[[Category: Human]]
[[Category: Stebbins, C E.]]
[[Category: Nesic, D]]
[[Category: Stebbins, C E]]
[[Category: Protein binding]]
[[Category: Protein binding]]
[[Category: Virulence factor and tumor suppressor]]
[[Category: Virulence factor and tumor suppressor]]
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