2zaz: Difference between revisions
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[[Image:2zaz.jpg|left|200px]] | [[Image:2zaz.jpg|left|200px]] | ||
'''Crystal structure of P38 in complex with 4-anilino quinoline inhibitor''' | {{Structure | ||
|PDB= 2zaz |SIZE=350|CAPTION= <scene name='initialview01'>2zaz</scene>, resolution 1.800Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GK1:'>GK1</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] | |||
|GENE= | |||
}} | |||
'''Crystal structure of P38 in complex with 4-anilino quinoline inhibitor''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2ZAZ is a [ | 2ZAZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZAZ OCA]. | ||
==Reference== | ==Reference== | ||
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:[http:// | Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18006306 18006306] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mitogen-activated protein kinase]] | [[Category: Mitogen-activated protein kinase]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:53:26 2008'' | ||
Revision as of 16:53, 20 March 2008
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| 2zaz, resolution 1.800Å | |||||||||||||
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| Ligands: | ACT, GK1 and GOL | ||||||||||||
| Activity: | Mitogen-activated protein kinase, with EC number 2.7.11.24 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of P38 in complex with 4-anilino quinoline inhibitor
Overview
The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.
About this Structure
2ZAZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:18006306
Page seeded by OCA on Thu Mar 20 18:53:26 2008
