3amv: Difference between revisions

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[[Image:3amv.jpg|left|200px]]<br /><applet load="3amv" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:3amv.jpg|left|200px]]
caption="3amv, resolution 2.1&Aring;" />
 
'''ALLOSTERIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG'''<br />
{{Structure
|PDB= 3amv |SIZE=350|CAPTION= <scene name='initialview01'>3amv</scene>, resolution 2.1&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>, <scene name='pdbligand=PO3:PHOSPHITE+ION'>PO3</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5'-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=BIN:2,3-DICARBOXY-4-(2-CHLORO-PHENYL)-1-ETHYL-5-ISOPROPOXYCARBONYL-6-METHYL-PYRIDINIUM'>BIN</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1]
|GENE=
}}
 
'''ALLOSTERIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
3AMV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] with <scene name='pdbligand=GLC:'>GLC</scene>, <scene name='pdbligand=PO3:'>PO3</scene>, <scene name='pdbligand=PLP:'>PLP</scene>, <scene name='pdbligand=BIN:'>BIN</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AMV OCA].  
3AMV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AMV OCA].  


==Reference==
==Reference==
Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate., Oikonomakos NG, Tsitsanou KE, Zographos SE, Skamnaki VT, Goldmann S, Bischoff H, Protein Sci. 1999 Oct;8(10):1930-45. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10548038 10548038]
Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate., Oikonomakos NG, Tsitsanou KE, Zographos SE, Skamnaki VT, Goldmann S, Bischoff H, Protein Sci. 1999 Oct;8(10):1930-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10548038 10548038]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Phosphorylase]]
[[Category: Phosphorylase]]
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[[Category: glycogen metabolism]]
[[Category: glycogen metabolism]]
[[Category: inhibition]]
[[Category: inhibition]]
[[Category: phosphorylase a]]
[[Category: phosphorylase some]]
[[Category: transferase]]
[[Category: transferase]]


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