4nsc: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4nsc|  PDB=4nsc  |  SCENE=  }}
+===Crystal Structure of CBARA1 in the Apo-form===
+{{ABSTRACT_PUBMED_24514027}}
-The entry 4nsc is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/MICU1_HUMAN MICU1_HUMAN]] Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. Acts as a gatekeeper that senses calcium level via its EF-hand domains and sets a threshold for mitochondrial calcium uptake by MCU, thereby preventing mitochondrial calcium overload. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.<ref>PMID:16002733</ref> <ref>PMID:20693986</ref> <ref>PMID:23101630</ref> <ref>PMID:22904319</ref>
-Authors: Wang, L., Yang, X., Li, S., Shen, Y.
+==About this Structure==
+[[4nsc]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NSC OCA].
-Description:
+==Reference==
+<ref group="xtra">PMID:024514027</ref><references group="xtra"/><references/>
+[[Category: Li, S.]]
+[[Category: Shen, Y.]]
+[[Category: Wang, L.]]
+[[Category: Yang, X.]]
+[[Category: Calcium binding protein]]
+[[Category: Ef-hand]]

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