3wkt: Difference between revisions

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{{STRUCTURE_3wkt|  PDB=3wkt  |  SCENE=  }}
==Complex structure of an open form of NADPH-cytochrome P450 reductase and heme oxygenase-1==
===Complex structure of an open form of NADPH-cytochrome P450 reductase and heme oxygenase-1===
<StructureSection load='3wkt' size='340' side='right' caption='[[3wkt]], [[Resolution|resolution]] 4.30&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[3wkt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WKT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WKT FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/NCPR_RAT NCPR_RAT]] This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. [[http://www.uniprot.org/uniprot/HMOX1_RAT HMOX1_RAT]] Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
 
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Por ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Hmox1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
==About this Structure==
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NADPH--hemoprotein_reductase NADPH--hemoprotein reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.2.4 1.6.2.4] </span></td></tr>
[[3wkt]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WKT OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wkt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wkt RCSB], [http://www.ebi.ac.uk/pdbsum/3wkt PDBsum]</span></td></tr>
</table>
__TOC__
</StructureSection>
[[Category: Buffalo rat]]
[[Category: NADPH--hemoprotein reductase]]
[[Category: NADPH--hemoprotein reductase]]
[[Category: Fukuyama, K.]]
[[Category: Fukuyama, K]]
[[Category: Harada, J.]]
[[Category: Harada, J]]
[[Category: Higashimoto, Y.]]
[[Category: Higashimoto, Y]]
[[Category: Noguchi, M.]]
[[Category: Noguchi, M]]
[[Category: Sato, H.]]
[[Category: Sato, H]]
[[Category: Sugishima, M.]]
[[Category: Sugishima, M]]
[[Category: Wada, K.]]
[[Category: Wada, K]]
[[Category: Heme degradation]]
[[Category: Heme degradation]]
[[Category: Microsomal membrane]]
[[Category: Microsomal membrane]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]

Revision as of 16:39, 21 December 2014

Complex structure of an open form of NADPH-cytochrome P450 reductase and heme oxygenase-1

3wkt, resolution 4.30Å

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