3b99: Difference between revisions

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[[Image:3b99.jpg|left|200px]]<br /><applet load="3b99" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:3b99.jpg|left|200px]]
caption="3b99, resolution 2.5&Aring;" />
 
'''Crystal structure of zebrafish prostacyclin synthase (cytochrome P450 8A1) in complex with substrate analog U51605'''<br />
{{Structure
|PDB= 3b99 |SIZE=350|CAPTION= <scene name='initialview01'>3b99</scene>, resolution 2.5&Aring;
|SITE= <scene name='pdbsite=AC1:Hem+Binding+Site+For+Residue+A+600'>AC1</scene>, <scene name='pdbsite=AC2:U51+Binding+Site+For+Residue+A+700'>AC2</scene>, <scene name='pdbsite=AC3:U51+Binding+Site+For+Residue+A+701'>AC3</scene>, <scene name='pdbsite=AC4:U51+Binding+Site+For+Residue+A+702'>AC4</scene>, <scene name='pdbsite=AC5:Hem+Binding+Site+For+Residue+B+600'>AC5</scene>, <scene name='pdbsite=AC6:U51+Binding+Site+For+Residue+B+700'>AC6</scene>, <scene name='pdbsite=AC7:U51+Binding+Site+For+Residue+B+701'>AC7</scene> and <scene name='pdbsite=AC8:U51+Binding+Site+For+Residue+B+702'>AC8</scene>
|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=U51:(6E)-7-{6-[(1E)-OCT-1-ENYL]-2,3-DIAZABICYCLO[2.2.1]HEPT-2-EN-5-YL}HEPT-6-ENOIC ACID'>U51</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Prostaglandin-I_synthase Prostaglandin-I synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.4 5.3.99.4]
|GENE= PGIS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Danio rerio])
}}
 
'''Crystal structure of zebrafish prostacyclin synthase (cytochrome P450 8A1) in complex with substrate analog U51605'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
3B99 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio] with <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=U51:'>U51</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Prostaglandin-I_synthase Prostaglandin-I synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.4 5.3.99.4] Known structural/functional Sites: <scene name='pdbsite=AC1:Hem+Binding+Site+For+Residue+A+600'>AC1</scene>, <scene name='pdbsite=AC2:U51+Binding+Site+For+Residue+A+700'>AC2</scene>, <scene name='pdbsite=AC3:U51+Binding+Site+For+Residue+A+701'>AC3</scene>, <scene name='pdbsite=AC4:U51+Binding+Site+For+Residue+A+702'>AC4</scene>, <scene name='pdbsite=AC5:Hem+Binding+Site+For+Residue+B+600'>AC5</scene>, <scene name='pdbsite=AC6:U51+Binding+Site+For+Residue+B+700'>AC6</scene>, <scene name='pdbsite=AC7:U51+Binding+Site+For+Residue+B+701'>AC7</scene> and <scene name='pdbsite=AC8:U51+Binding+Site+For+Residue+B+702'>AC8</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B99 OCA].  
3B99 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B99 OCA].  


==Reference==
==Reference==
Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change., Li YC, Chiang CW, Yeh HC, Hsu PY, Whitby FG, Wang LH, Chan NL, J Biol Chem. 2008 Feb 1;283(5):2917-26. Epub 2007 Nov 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18032380 18032380]
Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change., Li YC, Chiang CW, Yeh HC, Hsu PY, Whitby FG, Wang LH, Chan NL, J Biol Chem. 2008 Feb 1;283(5):2917-26. Epub 2007 Nov 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18032380 18032380]
[[Category: Danio rerio]]
[[Category: Danio rerio]]
[[Category: Prostaglandin-I synthase]]
[[Category: Prostaglandin-I synthase]]
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[[Category: substrate analog-enzyme complex]]
[[Category: substrate analog-enzyme complex]]


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