4nn7: Difference between revisions
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{{STRUCTURE_4nn7| PDB=4nn7 | SCENE= }} | |||
===Cytokine receptor complex - Crystal form 2=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TSLP_MOUSE TSLP_MOUSE]] Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity). [[http://www.uniprot.org/uniprot/CRLF2_MOUSE CRLF2_MOUSE]] Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. [[http://www.uniprot.org/uniprot/IL7RA_MOUSE IL7RA_MOUSE]] Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). | |||
==About this Structure== | |||
[[4nn7]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NN7 OCA]. | |||
[[Category: Savvides, S N.]] | |||
[[Category: Schie, L van.]] | |||
[[Category: Verstraete, K.]] | |||
[[Category: Cell surface]] | |||
[[Category: Chr domain]] | |||
[[Category: Cytokine-cytokine receptor complex]] | |||
[[Category: Four helical bundle fold]] | |||
[[Category: Tslp cytokine signaling]] | |||
[[Category: Tslpr and il-7ralpha receptor]] | |||
Revision as of 09:40, 19 March 2014
Cytokine receptor complex - Crystal form 2
Function
[TSLP_MOUSE] Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity). [CRLF2_MOUSE] Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. [IL7RA_MOUSE] Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
About this Structure
4nn7 is a 3 chain structure. Full crystallographic information is available from OCA.
