4nzo: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 2,5-DI-O-BN-INSP4===

~~The entry 4nzo~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/VIP2_HUMAN VIP2_HUMAN]] Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.<ref>PMID:17690096</ref> <ref>PMID:17702752</ref>

~~Authors~~: ~~Wang, H~~.~~, Shears, S~~.B.

==About this Structure==

[[4nzo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZO OCA].

~~Description~~: ~~Crystal structure of the catalytic domain of PPIP5K2 in~~ complex ~~with AMPPNP and an Inhibitor~~

==Reference==

[[Category: Shears, S B.]]

[[Category: Wang, H.]]

[[Category: Atp-grasp fold]]

[[Category: Drug discovery]]

[[Category: Enzymology]]

[[Category: Inositol pyrophosphate kinase]]

[[Category: Inositol pyrophosphate]]

[[Category: Kinase]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4nzo|  PDB=4nzo  |  SCENE=  }}
+===Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 2,5-DI-O-BN-INSP4===
-The entry 4nzo is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/VIP2_HUMAN VIP2_HUMAN]] Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.<ref>PMID:17690096</ref> <ref>PMID:17702752</ref>
-Authors: Wang, H., Shears, S.B.
+==About this Structure==
+[[4nzo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZO OCA].
-Description: Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and an Inhibitor
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Shears, S B.]]
+[[Category: Wang, H.]]
+[[Category: Atp-grasp fold]]
+[[Category: Drug discovery]]
+[[Category: Enzymology]]
+[[Category: Inositol pyrophosphate kinase]]
+[[Category: Inositol pyrophosphate]]
+[[Category: Kinase]]
+[[Category: Transferase-transferase inhibitor complex]]