4o7q: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Crystal Structure of the F27G AIM2 Pyrin Domain Mutant and Similarities of its Self-association to DED/DED Interactions===

~~The entry 4o7q~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/AIM2_HUMAN AIM2_HUMAN]] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.<ref>PMID:16432157</ref> <ref>PMID:17726700</ref> <ref>PMID:19158679</ref> <ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:20566831</ref>

~~Authors~~: ~~Lu, A~~.~~, Kabaleeswaran, V~~.~~, Wu, H~~.

==About this Structure==

[[4o7q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O7Q OCA].

~~Description~~: ~~Crystal Structure of the F27G AIM2 Pyrin Domain Mutant and Similarities of its Self-association to DED~~/~~DED Interactions~~

==Reference==

[[Category: Kabaleeswaran, V.]]

[[Category: Lu, A.]]

[[Category: Wu, H.]]

[[Category: Apoptosis]]

[[Category: Inflammasome]]

[[Category: Pyd/dd]]

[[Category: Signal transduction]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4o7q|  PDB=4o7q  |  SCENE=  }}
+===Crystal Structure of the F27G AIM2 Pyrin Domain Mutant and Similarities of its Self-association to DED/DED Interactions===
+{{ABSTRACT_PUBMED_24406744}}
-The entry 4o7q is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/AIM2_HUMAN AIM2_HUMAN]] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.<ref>PMID:16432157</ref> <ref>PMID:17726700</ref> <ref>PMID:19158679</ref> <ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:20566831</ref>
-Authors: Lu, A., Kabaleeswaran, V., Wu, H.
+==About this Structure==
+[[4o7q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O7Q OCA].
-Description: Crystal Structure of the F27G AIM2 Pyrin Domain Mutant and Similarities of its Self-association to DED/DED Interactions
+==Reference==
+<ref group="xtra">PMID:024406744</ref><references group="xtra"/><references/>
+[[Category: Kabaleeswaran, V.]]
+[[Category: Lu, A.]]
+[[Category: Wu, H.]]
+[[Category: Apoptosis]]
+[[Category: Inflammasome]]
+[[Category: Pyd/dd]]
+[[Category: Signal transduction]]
+[[Category: Signaling protein]]