4om2: Difference between revisions
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{{STRUCTURE_4om2| PDB=4om2 | SCENE= }} | |||
===Crystal structure of TLE1 N-terminal Q-domain residues 1-156=== | |||
{{ABSTRACT_PUBMED_24596249}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/TLE1_HUMAN TLE1_HUMAN]] Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.<ref>PMID:10660609</ref> | |||
==About this Structure== | |||
[[4om2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OM2 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024596249</ref><references group="xtra"/><references/> | |||
[[Category: Chodaparambil, J V.]] | |||
[[Category: Weis, W I.]] | |||
[[Category: Dna binding]] | |||
[[Category: Helix-turn-helix]] | |||
[[Category: Tcf/lef]] | |||
[[Category: Tetramer]] | |||
[[Category: Transcription]] | |||
[[Category: Wnt repressor]] | |||
